Validation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity Questionnaire for the Latin American Population
Background. Chemotherapy-induced peripheral neuropathy is a common adverse effect of chemotherapeutic treatment and is associated with decreased quality of life. The aim of this study was to evaluate the validity and reliability of the neurotoxicity subscale of the Functional Assessment of Cancer Th...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2022/6533797 |
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| author | Ivana Leao Ribeiro Luz Alejandra Lorca Rodrigo Cuevas-Cid Snehil Dixit Nicolás Yáñez-Benavides Francisco Ortega-Gonzalez |
| author_facet | Ivana Leao Ribeiro Luz Alejandra Lorca Rodrigo Cuevas-Cid Snehil Dixit Nicolás Yáñez-Benavides Francisco Ortega-Gonzalez |
| author_sort | Ivana Leao Ribeiro |
| collection | DOAJ |
| description | Background. Chemotherapy-induced peripheral neuropathy is a common adverse effect of chemotherapeutic treatment and is associated with decreased quality of life. The aim of this study was to evaluate the validity and reliability of the neurotoxicity subscale of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) for the Chilean population. Methods. A cross-sectional study in which 101 participants with haematologic, colorectal, breast, gastric, gynaecological, and other types of cancer completed the FACT/GOG-Ntx. Content validity (n=14 health professionals evaluated the subscale in four categories: test-retest reliability (n=20 patients), dimensionality, internal consistency, and concurrent validity and discriminant validity. In all analyses, p<0.05 was considered significant. Results. There was an agreement among the evaluators for all categories of the subscale (Kendall’s coefficient, W=0.4, p<0.01) and moderate to high intrarater reliability (intraclass correlation coefficient=0.7–0.9). Of the 11 original items that make up the subscale, none was eliminated. The factor analysis generated four factors that represented 72.2% of the total variance. Cronbach’s α was 0.8 for the 11 items. Women showed greater compromise in emotional well-being and neurotoxicity symptoms compared with men, and age was directly correlated with the questions ‘I have difficulty hearing’ (r=0.2, p=0.019) and ‘I feel a noise or buzzing in my ears’ (r=0.2, p=0.03). Conclusion. The Chilean version of the FACT/GOG-Ntx neurotoxicity subscale is a valid and reliable scale for evaluating neurotoxicity symptoms in adult cancer survivors in Latin America. The scales also adequately distinguish between sex-based well-being among the afflicted population. |
| format | Article |
| id | doaj-art-21c9e852e8764eedb6efa2c8c0868f89 |
| institution | Kabale University |
| issn | 2090-3189 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-21c9e852e8764eedb6efa2c8c0868f892025-02-03T05:50:37ZengWileyInternational Journal of Breast Cancer2090-31892022-01-01202210.1155/2022/6533797Validation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity Questionnaire for the Latin American PopulationIvana Leao Ribeiro0Luz Alejandra Lorca1Rodrigo Cuevas-Cid2Snehil Dixit3Nicolás Yáñez-Benavides4Francisco Ortega-Gonzalez5Department of KinesiologyHospital del SalvadorDepartment of KinesiologyDepartment of Medical Rehabilitation SciencesSubdepartamento de Oncología - Hospital Clínico Regional ValdiviaFacultad de MedicinaBackground. Chemotherapy-induced peripheral neuropathy is a common adverse effect of chemotherapeutic treatment and is associated with decreased quality of life. The aim of this study was to evaluate the validity and reliability of the neurotoxicity subscale of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) for the Chilean population. Methods. A cross-sectional study in which 101 participants with haematologic, colorectal, breast, gastric, gynaecological, and other types of cancer completed the FACT/GOG-Ntx. Content validity (n=14 health professionals evaluated the subscale in four categories: test-retest reliability (n=20 patients), dimensionality, internal consistency, and concurrent validity and discriminant validity. In all analyses, p<0.05 was considered significant. Results. There was an agreement among the evaluators for all categories of the subscale (Kendall’s coefficient, W=0.4, p<0.01) and moderate to high intrarater reliability (intraclass correlation coefficient=0.7–0.9). Of the 11 original items that make up the subscale, none was eliminated. The factor analysis generated four factors that represented 72.2% of the total variance. Cronbach’s α was 0.8 for the 11 items. Women showed greater compromise in emotional well-being and neurotoxicity symptoms compared with men, and age was directly correlated with the questions ‘I have difficulty hearing’ (r=0.2, p=0.019) and ‘I feel a noise or buzzing in my ears’ (r=0.2, p=0.03). Conclusion. The Chilean version of the FACT/GOG-Ntx neurotoxicity subscale is a valid and reliable scale for evaluating neurotoxicity symptoms in adult cancer survivors in Latin America. The scales also adequately distinguish between sex-based well-being among the afflicted population.http://dx.doi.org/10.1155/2022/6533797 |
| spellingShingle | Ivana Leao Ribeiro Luz Alejandra Lorca Rodrigo Cuevas-Cid Snehil Dixit Nicolás Yáñez-Benavides Francisco Ortega-Gonzalez Validation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity Questionnaire for the Latin American Population International Journal of Breast Cancer |
| title | Validation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity Questionnaire for the Latin American Population |
| title_full | Validation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity Questionnaire for the Latin American Population |
| title_fullStr | Validation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity Questionnaire for the Latin American Population |
| title_full_unstemmed | Validation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity Questionnaire for the Latin American Population |
| title_short | Validation of the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group Neurotoxicity Questionnaire for the Latin American Population |
| title_sort | validation of the functional assessment of cancer therapy gynecologic oncology group neurotoxicity questionnaire for the latin american population |
| url | http://dx.doi.org/10.1155/2022/6533797 |
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