From genotype to phenotype: decoding mutations in blasts by holo-tomographic flow cytometry

From genotype to phenotype: decoding mutations in blasts by holo-tomographic flow cytometry

Abstract Cup-like nuclear morphological alterations in acute myeloid leukemia (AML) blasts have been widely correlated with Nucleophosmin 1 (NPM1) mutations. NPM1-mutated AML has earned recognition as a distinct entity among myeloid tumors, but the absence of a thoroughly established tool for its mo...

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Main Authors: Daniele Pirone, Concetta Di Natale, Maria Di Summa, Nicola Mosca, Giusy Giugliano, Michela Schiavo, Daniele Florio, Daniela Marasco, Pier Luca Maffettone, Lisa Miccio, Pasquale Memmolo, Pietro Ferraro
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Light: Science & Applications
Online Access:https://doi.org/10.1038/s41377-025-01913-y
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https://doi.org/10.1038/s41377-025-01913-y

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