Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors
Gastrointestinal tumors present a significant challenge for precision medicine due to their complexity, necessitating the development of more specific diagnostic tools and therapeutic agents. Recent advances have positioned coding and non-coding RNAs as emerging biomarkers for these malignancies, de...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-12-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/13/1/47 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832589030047350784 |
|---|---|
| author | Runhan Liu Jiaxin Zhou Xiaochen Chen Jie Zhang Qunzhi Chen Xiaoming Liu Kunhou Yao |
| author_facet | Runhan Liu Jiaxin Zhou Xiaochen Chen Jie Zhang Qunzhi Chen Xiaoming Liu Kunhou Yao |
| author_sort | Runhan Liu |
| collection | DOAJ |
| description | Gastrointestinal tumors present a significant challenge for precision medicine due to their complexity, necessitating the development of more specific diagnostic tools and therapeutic agents. Recent advances have positioned coding and non-coding RNAs as emerging biomarkers for these malignancies, detectable by liquid biopsies, and as innovative therapeutic agents. Many RNA-based therapeutics, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASO), have entered clinical trials or are available on the market. This review provides a narrative examination of the diagnostic and therapeutic potential of RNA in gastrointestinal cancers, with an emphasis on its application in precision medicine. This review discusses the current challenges, such as drug resistance and tumor metastasis, and highlights how RNA molecules can be leveraged for targeted detection and treatment. Additionally, this review categorizes specific diagnostic biomarkers and RNA therapeutic targets based on tissue type, offering a comprehensive analysis of their role in advancing precision medicine for gastrointestinal tumors. |
| format | Article |
| id | doaj-art-21a0cef59af646169625c6cbe77e5a7e |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj-art-21a0cef59af646169625c6cbe77e5a7e2025-01-24T13:23:50ZengMDPI AGBiomedicines2227-90592024-12-011314710.3390/biomedicines13010047Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal TumorsRunhan Liu0Jiaxin Zhou1Xiaochen Chen2Jie Zhang3Qunzhi Chen4Xiaoming Liu5Kunhou Yao6Department of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaSchool of Life Sciences, Henan University, Kaifeng 475004, ChinaSchool of Life Sciences, Henan University, Kaifeng 475004, ChinaSchool of Life Sciences, Henan University, Kaifeng 475004, ChinaSchool of Life Sciences, Henan University, Kaifeng 475004, ChinaDepartment of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaDepartment of Gastrointestinal Surgery, Huaihe Hospital of Henan University, Kaifeng 475000, ChinaGastrointestinal tumors present a significant challenge for precision medicine due to their complexity, necessitating the development of more specific diagnostic tools and therapeutic agents. Recent advances have positioned coding and non-coding RNAs as emerging biomarkers for these malignancies, detectable by liquid biopsies, and as innovative therapeutic agents. Many RNA-based therapeutics, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASO), have entered clinical trials or are available on the market. This review provides a narrative examination of the diagnostic and therapeutic potential of RNA in gastrointestinal cancers, with an emphasis on its application in precision medicine. This review discusses the current challenges, such as drug resistance and tumor metastasis, and highlights how RNA molecules can be leveraged for targeted detection and treatment. Additionally, this review categorizes specific diagnostic biomarkers and RNA therapeutic targets based on tissue type, offering a comprehensive analysis of their role in advancing precision medicine for gastrointestinal tumors.https://www.mdpi.com/2227-9059/13/1/47gastrointestinal tumorsRNAdiagnosisdrug resistanceprecision medicine |
| spellingShingle | Runhan Liu Jiaxin Zhou Xiaochen Chen Jie Zhang Qunzhi Chen Xiaoming Liu Kunhou Yao Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors Biomedicines gastrointestinal tumors RNA diagnosis drug resistance precision medicine |
| title | Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors |
| title_full | Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors |
| title_fullStr | Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors |
| title_full_unstemmed | Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors |
| title_short | Diagnostic and Therapeutic Advances of RNAs in Precision Medicine of Gastrointestinal Tumors |
| title_sort | diagnostic and therapeutic advances of rnas in precision medicine of gastrointestinal tumors |
| topic | gastrointestinal tumors RNA diagnosis drug resistance precision medicine |
| url | https://www.mdpi.com/2227-9059/13/1/47 |
| work_keys_str_mv | AT runhanliu diagnosticandtherapeuticadvancesofrnasinprecisionmedicineofgastrointestinaltumors AT jiaxinzhou diagnosticandtherapeuticadvancesofrnasinprecisionmedicineofgastrointestinaltumors AT xiaochenchen diagnosticandtherapeuticadvancesofrnasinprecisionmedicineofgastrointestinaltumors AT jiezhang diagnosticandtherapeuticadvancesofrnasinprecisionmedicineofgastrointestinaltumors AT qunzhichen diagnosticandtherapeuticadvancesofrnasinprecisionmedicineofgastrointestinaltumors AT xiaomingliu diagnosticandtherapeuticadvancesofrnasinprecisionmedicineofgastrointestinaltumors AT kunhouyao diagnosticandtherapeuticadvancesofrnasinprecisionmedicineofgastrointestinaltumors |