RETRACTED: A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice

RETRACTED: A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice

Metabolic endotoxemia has been suggested to play a role in the pathophysiology of metaflammation, insulin-resistance and ultimately type-2 diabetes mellitus (T2DM). The role of endogenous antimicrobial peptides (AMPs), such as the cathelicidin LL-37, in T2DM is unknown. We report here for the first...

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Main Authors: Shireen Mohammad, Sura Al Zoubi, Debora Collotta, Nadine Krieg, Bianka Wissuwa, Gustavo Ferreira Alves, Gareth S. D. Purvis, Giuseppe Danilo Norata, Andrea Baragetti, Alberico Luigi Catapano, Egle Solito, Elisabeth Zechendorf, Tobias Schürholz, Wilmar Correa-Vargas, Klaus Brandenburg, Sina M. Coldewey, Massimo Collino, Muhammad M. Yaqoob, Lukas Martin, Christoph Thiemermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
peptide 19-2.5
high-fat diet
type-2 diabetes
antimicrobial peptide
insulin resistance
steatohepatitis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.701275/full
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