Aging Adults and Seasonal Influenza: Does the Vitamin D Status (H)Arm the Body?
Vitamin D (VitD), although originally described as an essential hormone for bone and mineral homeostasis, appears to have an active role in regulating specific facets of human immunity. Indeed, VitD has been shown to have significant effects on cytokine production and lymphocyte proliferation. Evide...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.1155/2012/806198 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556107480956928 |
|---|---|
| author | Pierre Olivier Lang Dimitrios Samaras |
| author_facet | Pierre Olivier Lang Dimitrios Samaras |
| author_sort | Pierre Olivier Lang |
| collection | DOAJ |
| description | Vitamin D (VitD), although originally described as an essential hormone for bone and mineral homeostasis, appears to have an active role in regulating specific facets of human immunity. Indeed, VitD has been shown to have significant effects on cytokine production and lymphocyte proliferation. Evidence that VitD affects clearance of selected pathogens is supported by epidemiological and clinical data, while its coadministration with influenza vaccine in mice enhanced both mucosal and systemic antibody responses. This paper aims to examine how VitD may contribute to limiting the burden of influenza infection in the aging and aged adults, a population in which this burden remains considerable. Furthermore, we discuss how VitD status may play a role in host resistance to influenza virus and influence the immunogenicity of the influenza vaccines currently licensed for adults aged 65 years or over by its effects on innate and adaptive immunities. |
| format | Article |
| id | doaj-art-212d5f7035c04c27a89bc7531d25cf8d |
| institution | Kabale University |
| issn | 2090-2204 2090-2212 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-212d5f7035c04c27a89bc7531d25cf8d2025-02-03T05:46:19ZengWileyJournal of Aging Research2090-22042090-22122012-01-01201210.1155/2012/806198806198Aging Adults and Seasonal Influenza: Does the Vitamin D Status (H)Arm the Body?Pierre Olivier Lang0Dimitrios Samaras1Department of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Hospital of Trois-Chêne, Chemin du Pont-Bochet 3, CH-1226 Thônex-Geneva, SwitzerlandDepartment of Internal Medicine, Rehabilitation and Geriatrics, Medical School and University Hospitals of Geneva, Hospital of Trois-Chêne, Chemin du Pont-Bochet 3, CH-1226 Thônex-Geneva, SwitzerlandVitamin D (VitD), although originally described as an essential hormone for bone and mineral homeostasis, appears to have an active role in regulating specific facets of human immunity. Indeed, VitD has been shown to have significant effects on cytokine production and lymphocyte proliferation. Evidence that VitD affects clearance of selected pathogens is supported by epidemiological and clinical data, while its coadministration with influenza vaccine in mice enhanced both mucosal and systemic antibody responses. This paper aims to examine how VitD may contribute to limiting the burden of influenza infection in the aging and aged adults, a population in which this burden remains considerable. Furthermore, we discuss how VitD status may play a role in host resistance to influenza virus and influence the immunogenicity of the influenza vaccines currently licensed for adults aged 65 years or over by its effects on innate and adaptive immunities.http://dx.doi.org/10.1155/2012/806198 |
| spellingShingle | Pierre Olivier Lang Dimitrios Samaras Aging Adults and Seasonal Influenza: Does the Vitamin D Status (H)Arm the Body? Journal of Aging Research |
| title | Aging Adults and Seasonal Influenza: Does the Vitamin D Status (H)Arm the Body? |
| title_full | Aging Adults and Seasonal Influenza: Does the Vitamin D Status (H)Arm the Body? |
| title_fullStr | Aging Adults and Seasonal Influenza: Does the Vitamin D Status (H)Arm the Body? |
| title_full_unstemmed | Aging Adults and Seasonal Influenza: Does the Vitamin D Status (H)Arm the Body? |
| title_short | Aging Adults and Seasonal Influenza: Does the Vitamin D Status (H)Arm the Body? |
| title_sort | aging adults and seasonal influenza does the vitamin d status h arm the body |
| url | http://dx.doi.org/10.1155/2012/806198 |
| work_keys_str_mv | AT pierreolivierlang agingadultsandseasonalinfluenzadoesthevitamindstatusharmthebody AT dimitriossamaras agingadultsandseasonalinfluenzadoesthevitamindstatusharmthebody |