Brief communication: virological outcomes and dolutegravir resistance mutations in HIV-infected patients: a multicenter retrospective cohort study in Mozambique
Abstract The global HIV epidemic remains a major public health challenge, with DTG playing a key role in ART regimens due to its efficacy and tolerability. This study evaluated virological outcomes and resistance mutations in patients on DTG in Mozambique through a retrospective cohort study in seve...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | AIDS Research and Therapy |
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| Online Access: | https://doi.org/10.1186/s12981-025-00708-w |
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| author | Anna Maria Doro Altan Noorjehan Majid Stefano Orlando Elton Uamusse Marcia Rafael Zita Sidumo Giovanni Guidotti Fausto Ciccacci |
| author_facet | Anna Maria Doro Altan Noorjehan Majid Stefano Orlando Elton Uamusse Marcia Rafael Zita Sidumo Giovanni Guidotti Fausto Ciccacci |
| author_sort | Anna Maria Doro Altan |
| collection | DOAJ |
| description | Abstract The global HIV epidemic remains a major public health challenge, with DTG playing a key role in ART regimens due to its efficacy and tolerability. This study evaluated virological outcomes and resistance mutations in patients on DTG in Mozambique through a retrospective cohort study in seven DREAM centers. Data from 29,601 patients (98.1% on DTG) revealed a virological suppression rate of 95% (27,622/29,051). Factors positively associated with suppression included age > 50, longer ART duration, and being female. Of 17 resistance tests, 8 showed major mutations, including G118R and E138K. Results highlight DTG’s effectiveness and the need for resistance surveillance. |
| format | Article |
| id | doaj-art-212701b9adf34591a13e490ace76d9db |
| institution | Kabale University |
| issn | 1742-6405 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | AIDS Research and Therapy |
| spelling | doaj-art-212701b9adf34591a13e490ace76d9db2025-02-02T12:43:20ZengBMCAIDS Research and Therapy1742-64052025-01-012211510.1186/s12981-025-00708-wBrief communication: virological outcomes and dolutegravir resistance mutations in HIV-infected patients: a multicenter retrospective cohort study in MozambiqueAnna Maria Doro Altan0Noorjehan Majid1Stefano Orlando2Elton Uamusse3Marcia Rafael4Zita Sidumo5Giovanni Guidotti6Fausto Ciccacci7DREAM Program, Community of Sant’EgidioDREAM Program, Community of Sant’EgidioDepartment of Biomedicine and Prevention, University of Rome Tor VergataDREAM Program, Community of Sant’EgidioDREAM Program, Community of Sant’EgidioDREAM Program, Community of Sant’EgidioASL Roma 1Department of Biomedicine and Prevention, University of Rome Tor VergataAbstract The global HIV epidemic remains a major public health challenge, with DTG playing a key role in ART regimens due to its efficacy and tolerability. This study evaluated virological outcomes and resistance mutations in patients on DTG in Mozambique through a retrospective cohort study in seven DREAM centers. Data from 29,601 patients (98.1% on DTG) revealed a virological suppression rate of 95% (27,622/29,051). Factors positively associated with suppression included age > 50, longer ART duration, and being female. Of 17 resistance tests, 8 showed major mutations, including G118R and E138K. Results highlight DTG’s effectiveness and the need for resistance surveillance.https://doi.org/10.1186/s12981-025-00708-wHIVDrug resistanceDolutegravirAntiretroviral therapyAfrica |
| spellingShingle | Anna Maria Doro Altan Noorjehan Majid Stefano Orlando Elton Uamusse Marcia Rafael Zita Sidumo Giovanni Guidotti Fausto Ciccacci Brief communication: virological outcomes and dolutegravir resistance mutations in HIV-infected patients: a multicenter retrospective cohort study in Mozambique AIDS Research and Therapy HIV Drug resistance Dolutegravir Antiretroviral therapy Africa |
| title | Brief communication: virological outcomes and dolutegravir resistance mutations in HIV-infected patients: a multicenter retrospective cohort study in Mozambique |
| title_full | Brief communication: virological outcomes and dolutegravir resistance mutations in HIV-infected patients: a multicenter retrospective cohort study in Mozambique |
| title_fullStr | Brief communication: virological outcomes and dolutegravir resistance mutations in HIV-infected patients: a multicenter retrospective cohort study in Mozambique |
| title_full_unstemmed | Brief communication: virological outcomes and dolutegravir resistance mutations in HIV-infected patients: a multicenter retrospective cohort study in Mozambique |
| title_short | Brief communication: virological outcomes and dolutegravir resistance mutations in HIV-infected patients: a multicenter retrospective cohort study in Mozambique |
| title_sort | brief communication virological outcomes and dolutegravir resistance mutations in hiv infected patients a multicenter retrospective cohort study in mozambique |
| topic | HIV Drug resistance Dolutegravir Antiretroviral therapy Africa |
| url | https://doi.org/10.1186/s12981-025-00708-w |
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