Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown
Systemic lupus erythematosus is characterized by a breakdown of self-tolerance and production of autoantibodies. Kidney involvement (i.e., lupus nephritis) is both common and severe and can result in permanent damage within the glomerular, vascular, and tubulo-interstitial compartments of the kidney...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/139365 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559333938823168 |
|---|---|
| author | Susan Yung Tak Mao Chan |
| author_facet | Susan Yung Tak Mao Chan |
| author_sort | Susan Yung |
| collection | DOAJ |
| description | Systemic lupus erythematosus is characterized by a breakdown of self-tolerance and production of autoantibodies. Kidney involvement (i.e., lupus nephritis) is both common and severe and can result in permanent damage within the glomerular, vascular, and tubulo-interstitial compartments of the kidney, leading to acute or chronic renal failure. Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface proteins of resident kidney cells, thereby triggering the downstream activation of signaling pathways and the release of mediators of inflammation and fibrosis. This paper describes the mechanisms through which autoantibodies interact with resident renal cells and how this interaction plays a part in disease pathogenesis that ultimately leads to structural and functional alterations in lupus nephritis. |
| format | Article |
| id | doaj-art-212623cc24b34c5fb095502c0a0e78c0 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-212623cc24b34c5fb095502c0a0e78c02025-02-03T01:30:13ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/139365139365Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the UnknownSusan Yung0Tak Mao Chan1Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong KongDepartment of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam, Hong KongSystemic lupus erythematosus is characterized by a breakdown of self-tolerance and production of autoantibodies. Kidney involvement (i.e., lupus nephritis) is both common and severe and can result in permanent damage within the glomerular, vascular, and tubulo-interstitial compartments of the kidney, leading to acute or chronic renal failure. Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface proteins of resident kidney cells, thereby triggering the downstream activation of signaling pathways and the release of mediators of inflammation and fibrosis. This paper describes the mechanisms through which autoantibodies interact with resident renal cells and how this interaction plays a part in disease pathogenesis that ultimately leads to structural and functional alterations in lupus nephritis.http://dx.doi.org/10.1155/2012/139365 |
| spellingShingle | Susan Yung Tak Mao Chan Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown Clinical and Developmental Immunology |
| title | Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown |
| title_full | Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown |
| title_fullStr | Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown |
| title_full_unstemmed | Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown |
| title_short | Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis: Getting to Know the Unknown |
| title_sort | autoantibodies and resident renal cells in the pathogenesis of lupus nephritis getting to know the unknown |
| url | http://dx.doi.org/10.1155/2012/139365 |
| work_keys_str_mv | AT susanyung autoantibodiesandresidentrenalcellsinthepathogenesisoflupusnephritisgettingtoknowtheunknown AT takmaochan autoantibodiesandresidentrenalcellsinthepathogenesisoflupusnephritisgettingtoknowtheunknown |