Melatonin attenuates degenerative disc degression by downregulating DLX5 via the TGF/Smad2/3 pathway in nucleus pulposus cells

Melatonin attenuates degenerative disc degression by downregulating DLX5 via the TGF/Smad2/3 pathway in nucleus pulposus cells

Abstract Background Intervertebral disc degeneration (IVDD) is the leading cause of low back pain, and apoptosis plays a key role in its pathogenesis. Distal‐less homeobox 5 (Dlx5) has been reported to induce cell apoptosis. Melatonin, as a powerful antiapoptotic agent, has been widely reported. Aim...

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Bibliographic Details
Main Authors: Kuibo Zhang, Hua Wang, Ling Mo, Xiaohui Huang, Chao Yuan, Caijun Liu
Format: Article
Language:English
Published: Wiley 2024-12-01
Series:JOR Spine
Subjects:
apoptosis
DLX5
intervertebral disc degeneration
melatonin
nucleus pulposus cell
Online Access:https://doi.org/10.1002/jsp2.70014
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https://doi.org/10.1002/jsp2.70014

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