Dynamic single-cell systemic immune responses in immunotherapy-treated early-stage HR+ breast cancer patients

Abstract The limited added benefit of immune checkpoint inhibitors in breast cancer indicates the pressing need to identify biomarkers of response to minimize risk and maximize benefit. We used single cell RNA sequencing and T cell receptor (TCR) sequencing of peripheral blood mononuclear cells (for...

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Bibliographic Details
Main Authors: Xiaopeng Sun, Margaret L. Axelrod, Adrienne G. Waks, Jingxin Fu, Molly DiLullo, Eliezer M. Van Allen, Sara M. Tolaney, Elizabeth A. Mittendorf, Yaomin Xu, Justin M. Balko
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-025-00776-1
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