Intrathecal activation of CD8+ memory T cells in IgG4‐related disease of the brain parenchyma

Intrathecal activation of CD8+ memory T cells in IgG4‐related disease of the brain parenchyma

Abstract IgG4‐related disease (IgG4‐RD) is a fibroinflammatory disorder signified by aberrant infiltration of IgG4‐restricted plasma cells into a variety of organs. Clinical presentation is heterogeneous, and pathophysiological mechanisms of IgG4‐RD remain elusive. There are very few cases of IgG4‐R...

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Main Authors: Mirco Friedrich, Niklas Kehl, Niko Engelke, Josephine Kraus, Katharina Lindner, Philipp Münch, Iris Mildenberger, Christoph Groden, Achim Gass, Nima Etminan, Marc Fatar, Andreas von Deimling, David Reuss, Michael Platten, Lukas Bunse
Format: Article
Language:English
Published: Springer Nature 2021-07-01
Series:EMBO Molecular Medicine
Subjects:
CSF single‐cell sequencing
cytotoxic T helper cell
IgG4‐related disease
inflammatory pseudotumor
pathogenic B‐cell
Online Access:https://doi.org/10.15252/emmm.202113953
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https://doi.org/10.15252/emmm.202113953

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