No Correlation Exists between Disease Activity and the Expression of Killer-Cell Immunoglobulin-Like Receptors in Patients with Rheumatoid Arthritis
Objective. The genes for killer-cell immunoglobulin-like receptors (KIRs) have been cloned and their functions and expression in patients with rheumatoid arthritis (RA) have been partially clarified. However, the correlation between their expression and disease activity has not been analyzed in pati...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2007-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/65179 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567497919823872 |
|---|---|
| author | Toshiaki Kogure Takeshi Tatsumi Atsushi Niizawa Hiroshi Fujinaga Tomoyuki Ito Yutaka Shimada Katsutoshi Terasawa |
| author_facet | Toshiaki Kogure Takeshi Tatsumi Atsushi Niizawa Hiroshi Fujinaga Tomoyuki Ito Yutaka Shimada Katsutoshi Terasawa |
| author_sort | Toshiaki Kogure |
| collection | DOAJ |
| description | Objective. The genes for killer-cell immunoglobulin-like receptors (KIRs) have been cloned and their functions and expression in patients with rheumatoid arthritis (RA) have been partially clarified. However, the correlation between their expression and disease activity has not been analyzed in patients with RA. Thus, we measured KIR expression on lymphocytes in patients with RA, and assessed the correlation between KIR expression and disease activity. Patients and Methods. In the cross-sectional study, 15 patients (9 females and 6 males) who fulfilled the diagnostic criteria for RA were assessed. In the longitudinal study, patients who were followed-up for 3 months were assessed. CD158a/b expression on peripheral blood mononuclear cells (PBMC) of RA patients was analyzed using flow cytometry. Results. No significant correlation between KIR expression and CRP, ESR, or IgM-RF was observed. There was no remarkable change in the expression of KIRs between the baseline and after 3 months. Additionally, in the 5 patients whose expression of KIRs particularly changed, the time-related changes in the expression of KIRs were independent from those of inflammation parameters and IgM-RF. Conclusion. There was no correlation between KIR expression and disease activity; therefore, the clinical use of KIR expression should be limited, while unnatural KIR expression may be involved in the pathogenesis of RA, but not a recruitment of chronic inflammation to induce joint damage. |
| format | Article |
| id | doaj-art-208574d3d3094e35835aa6b5f87a6466 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-208574d3d3094e35835aa6b5f87a64662025-02-03T01:01:18ZengWileyMediators of Inflammation0962-93511466-18612007-01-01200710.1155/2007/6517965179No Correlation Exists between Disease Activity and the Expression of Killer-Cell Immunoglobulin-Like Receptors in Patients with Rheumatoid ArthritisToshiaki Kogure0Takeshi Tatsumi1Atsushi Niizawa2Hiroshi Fujinaga3Tomoyuki Ito4Yutaka Shimada5Katsutoshi Terasawa6Department of Integrated Japanese Oriental Medicine, School of Medicine, Gunma University, 3-39-22 Showa-Machi, Maebashi 371-8511, JapanDepartment of Integrated Japanese Oriental Medicine, School of Medicine, Gunma University, 3-39-22 Showa-Machi, Maebashi 371-8511, JapanDepartment of Japanese Oriental Medicine, Kanebo Memorial Hospital, Misakicho 1-9-1 Hyogo-Ku, Kobe, Hyogo 652-0855, JapanDepartment of Japanese Oriental Medicine, Toyama Prefectural Central Hospital, 2-2-78 Nishinagae, Toyama 930-8550, JapanDepartment of Internal Medicine (Rheumatology), Nagaoka Red-Cross Hospital, 297-1 Terajima-Machi, Nagaoka, Niigata 940-2085, JapanDepartment of Japanese Oriental Medicine, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama-Shi, Toyama 930-0194, JapanDepartment of Japanese Oriental Medicine, Graduate School of Medicine, Chiba University, Chiba 260-8670, JapanObjective. The genes for killer-cell immunoglobulin-like receptors (KIRs) have been cloned and their functions and expression in patients with rheumatoid arthritis (RA) have been partially clarified. However, the correlation between their expression and disease activity has not been analyzed in patients with RA. Thus, we measured KIR expression on lymphocytes in patients with RA, and assessed the correlation between KIR expression and disease activity. Patients and Methods. In the cross-sectional study, 15 patients (9 females and 6 males) who fulfilled the diagnostic criteria for RA were assessed. In the longitudinal study, patients who were followed-up for 3 months were assessed. CD158a/b expression on peripheral blood mononuclear cells (PBMC) of RA patients was analyzed using flow cytometry. Results. No significant correlation between KIR expression and CRP, ESR, or IgM-RF was observed. There was no remarkable change in the expression of KIRs between the baseline and after 3 months. Additionally, in the 5 patients whose expression of KIRs particularly changed, the time-related changes in the expression of KIRs were independent from those of inflammation parameters and IgM-RF. Conclusion. There was no correlation between KIR expression and disease activity; therefore, the clinical use of KIR expression should be limited, while unnatural KIR expression may be involved in the pathogenesis of RA, but not a recruitment of chronic inflammation to induce joint damage.http://dx.doi.org/10.1155/2007/65179 |
| spellingShingle | Toshiaki Kogure Takeshi Tatsumi Atsushi Niizawa Hiroshi Fujinaga Tomoyuki Ito Yutaka Shimada Katsutoshi Terasawa No Correlation Exists between Disease Activity and the Expression of Killer-Cell Immunoglobulin-Like Receptors in Patients with Rheumatoid Arthritis Mediators of Inflammation |
| title | No Correlation Exists between Disease Activity and the Expression of Killer-Cell
Immunoglobulin-Like Receptors in Patients with Rheumatoid Arthritis |
| title_full | No Correlation Exists between Disease Activity and the Expression of Killer-Cell
Immunoglobulin-Like Receptors in Patients with Rheumatoid Arthritis |
| title_fullStr | No Correlation Exists between Disease Activity and the Expression of Killer-Cell
Immunoglobulin-Like Receptors in Patients with Rheumatoid Arthritis |
| title_full_unstemmed | No Correlation Exists between Disease Activity and the Expression of Killer-Cell
Immunoglobulin-Like Receptors in Patients with Rheumatoid Arthritis |
| title_short | No Correlation Exists between Disease Activity and the Expression of Killer-Cell
Immunoglobulin-Like Receptors in Patients with Rheumatoid Arthritis |
| title_sort | no correlation exists between disease activity and the expression of killer cell immunoglobulin like receptors in patients with rheumatoid arthritis |
| url | http://dx.doi.org/10.1155/2007/65179 |
| work_keys_str_mv | AT toshiakikogure nocorrelationexistsbetweendiseaseactivityandtheexpressionofkillercellimmunoglobulinlikereceptorsinpatientswithrheumatoidarthritis AT takeshitatsumi nocorrelationexistsbetweendiseaseactivityandtheexpressionofkillercellimmunoglobulinlikereceptorsinpatientswithrheumatoidarthritis AT atsushiniizawa nocorrelationexistsbetweendiseaseactivityandtheexpressionofkillercellimmunoglobulinlikereceptorsinpatientswithrheumatoidarthritis AT hiroshifujinaga nocorrelationexistsbetweendiseaseactivityandtheexpressionofkillercellimmunoglobulinlikereceptorsinpatientswithrheumatoidarthritis AT tomoyukiito nocorrelationexistsbetweendiseaseactivityandtheexpressionofkillercellimmunoglobulinlikereceptorsinpatientswithrheumatoidarthritis AT yutakashimada nocorrelationexistsbetweendiseaseactivityandtheexpressionofkillercellimmunoglobulinlikereceptorsinpatientswithrheumatoidarthritis AT katsutoshiterasawa nocorrelationexistsbetweendiseaseactivityandtheexpressionofkillercellimmunoglobulinlikereceptorsinpatientswithrheumatoidarthritis |