Developmental air pollution exposure augments airway hyperreactivity, alters transcriptome, and DNA methylation in female adult progeny

Abstract Maternal exposure to particulate air pollution increases the incidence and severity of asthma in offspring, yet the mechanisms for this are unclear. Known susceptibility loci are a minor component of this effect. We interrogate a mouse allergic airway disease model to assess epigenetic asso...

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Bibliographic Details
Main Authors: Razia Zakarya, Yik Lung Chan, Baoming Wang, Andrew Thorpe, Single-Cell Mouse Lung Disease Atlas Consortium, Dikaia Xenaki, Kin Fai Ho, Hai Guo, Hui Chen, Brian G. Oliver, Christopher O’Neill
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07835-0
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