Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology
The aim of this research was to formulate effervescent floating drug delivery systems of theophylline using different release retarding polymers such as ethyl cellulose, Eudragit® L100, xanthan gum and polyethylene oxide (PEO) N12K. Sodium bicarbonate was used as a gas generating agent. Direct compr...
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| Format: | Article |
| Language: | English |
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Sciendo
2016-03-01
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| Series: | Acta Pharmaceutica |
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| Online Access: | https://doi.org/10.1515/acph-2016-0002 |
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| author | Srikanth Meka Venkata Ee Li Chew Sheshala Ravi |
| author_facet | Srikanth Meka Venkata Ee Li Chew Sheshala Ravi |
| author_sort | Srikanth Meka Venkata |
| collection | DOAJ |
| description | The aim of this research was to formulate effervescent floating drug delivery systems of theophylline using different release retarding polymers such as ethyl cellulose, Eudragit® L100, xanthan gum and polyethylene oxide (PEO) N12K. Sodium bicarbonate was used as a gas generating agent. Direct compression was used to formulate floating tablets and the tablets were evaluated for their physicochemical and dissolution characteristics. PEO based formulations produced better drug release properties than other formulations. Hence, it was further optimized by central composite design. Further subjects of research were the effect of formulation variables on floating lag time and the percentage of drug released at the seventh hour (D7h). The optimum quantities of PEO and sodium bicarbonate, which had the highest desirability close to 1.0, were chosen as the statistically optimized formulation. No interaction was found between theophylline and PEO by Fourier Transformation Infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) studies. |
| format | Article |
| id | doaj-art-2035c2a6e45f4b2c9ad1ba5bbf12f189 |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-2035c2a6e45f4b2c9ad1ba5bbf12f1892025-02-02T12:44:01ZengSciendoActa Pharmaceutica1846-95582016-03-01661355110.1515/acph-2016-0002acph-2016-0002Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodologySrikanth Meka Venkata0Ee Li Chew1Sheshala Ravi2School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaSchool of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, MalaysiaThe aim of this research was to formulate effervescent floating drug delivery systems of theophylline using different release retarding polymers such as ethyl cellulose, Eudragit® L100, xanthan gum and polyethylene oxide (PEO) N12K. Sodium bicarbonate was used as a gas generating agent. Direct compression was used to formulate floating tablets and the tablets were evaluated for their physicochemical and dissolution characteristics. PEO based formulations produced better drug release properties than other formulations. Hence, it was further optimized by central composite design. Further subjects of research were the effect of formulation variables on floating lag time and the percentage of drug released at the seventh hour (D7h). The optimum quantities of PEO and sodium bicarbonate, which had the highest desirability close to 1.0, were chosen as the statistically optimized formulation. No interaction was found between theophylline and PEO by Fourier Transformation Infrared spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) studies.https://doi.org/10.1515/acph-2016-0002theophyllinegastroretentivefloatingcentral compositepeo n12k |
| spellingShingle | Srikanth Meka Venkata Ee Li Chew Sheshala Ravi Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology Acta Pharmaceutica theophylline gastroretentive floating central composite peo n12k |
| title | Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology |
| title_full | Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology |
| title_fullStr | Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology |
| title_full_unstemmed | Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology |
| title_short | Design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology |
| title_sort | design and statistical optimization of an effervescent floating drug delivery system of theophylline using response surface methodology |
| topic | theophylline gastroretentive floating central composite peo n12k |
| url | https://doi.org/10.1515/acph-2016-0002 |
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