Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments

Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments

Abstract Tau proteins as neurofibrillary tangles are one of the molecular hallmarks of Alzheimer’s disease (AD) and play a central role in tauopathies, a group of age-related neurodegenerative disorders. The filament cores from diverse tauopathies share a common region of tau consisting of the R3-R4...

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Bibliographic Details
Main Authors: Léa El Hajjar, Emmanuelle Boll, François-Xavier Cantrelle, Clarisse Bridot, Isabelle Landrieu, Caroline Smet-Nocca
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Microtubule-associated tau protein
Tau fragments
Seeds
Fibrillar aggregation
Phosphorylation
GSK3β
Online Access:https://doi.org/10.1038/s41598-025-91867-3
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https://doi.org/10.1038/s41598-025-91867-3

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