An Anti‐CD147 Antibody−Drug Conjugate Mehozumab‐DM1 is Efficacious Against Hepatocellular Carcinoma in Cynomolgus Monkey

An Anti‐CD147 Antibody−Drug Conjugate Mehozumab‐DM1 is Efficacious Against Hepatocellular Carcinoma in Cynomolgus Monkey

Abstract Effective treatment strategies are urgently needed for hepatocellular carcinoma (HCC) patients due to frequent therapeutic resistance and recurrence. Antibody‐drug conjugate (ADC) is a specific antibody‐drug conjugated with small molecular compounds, which has potent killing activity agains...

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Main Authors: Wan Huang, Liping Zhong, Ying Shi, Qingzhi Ma, Xiangmin Yang, Hongmei Zhang, Jing Zhang, Ling Wang, Kun Wang, Jingzhuo Li, Jie Zou, Xu Yang, Liu Yang, Qingmei Zeng, Lin Jing, Zhi‐Nan Chen, Yongxiang Zhao
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
antibody‐drug conjugate
cell necroptosis
hepatocellular carcinoma
therapeutic resistance
Online Access:https://doi.org/10.1002/advs.202410438
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https://doi.org/10.1002/advs.202410438

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