ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma

ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma

Abstract Background Fork-head box protein M1 (FOXM1) plays critical roles in development and progression of multiple cancers, including hepatocellular carcinoma (HCC). However, the exact regulatory hierarchy of FOXM1 remains unclear. Here, a genome-wide screen is performed to identify intranuclear p...

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Main Authors: Xunliang Jiang, Jun Liu, Ke Wang, Jianyong Sun, Huilong Yin, Yu Jiang, Yongkang Liu, Ningbo Wang, Xiaochen Ding, Pu Gao, Lin Li, Xiang Zhang, Jipeng Li, Rui Zhang
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Genome Biology
Subjects:
Human hepatocellular carcinoma
Double positive feedback loop
Liquid–liquid phase separation
FOXM1
Protein degradation
Online Access:https://doi.org/10.1186/s13059-025-03526-5
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https://doi.org/10.1186/s13059-025-03526-5

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