A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation

A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation

Abstract Background C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune cell activation via unknown molecular...

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Main Authors: Ebru Karasu, Rebecca Halbgebauer, Lena Schütte, Johannes Greven, Felix M. Bläsius, Johannes Zeller, Oscar Winninger, David Braig, David Alexander Christian Messerer, Bettina Berger, Hendrik Feuerstein, Anke Schultze, Karlheinz Peter, Uwe Knippschild, Klemens Horst, Frank Hildebrand, Steffen U. Eisenhardt, Markus Huber-Lang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Biology
Subjects:
C-reactive-protein (CRP)
Monomeric CRP (mCRP)
Neutrophil activation
Neutrophil extracellular trap (NET)
Inflammation
Severe injury
Online Access:https://doi.org/10.1186/s12915-024-02093-8
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https://doi.org/10.1186/s12915-024-02093-8

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