Schistosomal cryoglobulinemia associated with vasculitis and glomerulonephritis Case report
Schistosomiasis is an endemic, widespread disease in the subtropics and is a major cause of morbidity in developing countries. This is a report of a patient with a high titer of cryoglobulins composed of monoclonal IgM and anti-schistosoma IgG adult worm antibodies. This was associated with vasculit...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2014-08-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | https://mjhid.org/index.php/mjhid/article/view/1931 |
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| Summary: | Schistosomiasis is an endemic, widespread disease in the subtropics and is a major cause of morbidity in developing countries. This is a report of a patient with a high titer of cryoglobulins composed of monoclonal IgM and anti-schistosoma IgG adult worm antibodies. This was associated with vasculitis and membranoproliferative glomerulonephritis. Improvement was noted after treatment with steroids and cyclophosphamide. This case presents 3 novel findings: first, it is the first documentation, that we could trace, of a clear link between schistosomiasis and type II “essential” mixed cryoglobulinemia in humans where anti-schostosomal antibodies form the IgG component of the cryoglobulins. Second, it reports vasculitis associated with the shcistosomal cryoglobulins and finally it is a uniquel report of shcistosomal glomerulopathy responsive to immune suppression. |
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| ISSN: | 2035-3006 |