Nuclear RhoA Activation Regulates Nucleus Size and DNA Content via Nuclear Activation of ROCK and pErk

RhoA is a major regulator of the actin cytoskeleton. Its function in the nucleus, however, is unclear. Fusing wildtype, fast cycling, constitutively active, and dominant negative forms of RhoA with tags promoting nuclear or cytoplasmic location and allowing specific detection, we established a platf...

Full description

Saved in:
Bibliographic Details
Main Authors: Lap P. Nguyen, Julius Svensmark, Xin Jiang, Alexander Jordan, Cord Brakebusch
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/14/6/404
Tags: Add Tag
No Tags, Be the first to tag this record!