Identification of novel amrR deletions as meropenem resistance mechanisms in clinical Burkholderia pseudomallei isolates

Identification of novel amrR deletions as meropenem resistance mechanisms in clinical Burkholderia pseudomallei isolates

ABSTRACT Burkholderia pseudomallei, an environmental bacterium, is the causative agent of melioidosis, a potentially fatal infectious disease predominantly found in tropical regions. Despite the bacterium’s intrinsic resistance to numerous antibiotics, the antibiotic resistance mechanisms remain poo...

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Main Authors: Supichaya Nimnuan-ngam, Shirley Yi Fen Hii, Rathanin Seng, Natnaree Saiprom, Sarunporn Tandhavanant, T. Eoin West, Narisara Chantratita
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:Microbiology Spectrum
Subjects:
amrR mutation
AmrAB-OprA efflux pump
drug resistance
melioidosis
meropenem
Burkholderia pseudomallei
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01936-24
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https://journals.asm.org/doi/10.1128/spectrum.01936-24

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