Interactions of Nedaplatin with Nucleobases and Purine Alkaloids: Their Role in Cancer Therapy

Interactions of Nedaplatin with Nucleobases and Purine Alkaloids: Their Role in Cancer Therapy

<b>Background</b>: Nedaplatin is a platinum-based anticancer drug that combines the benefits of Cisplatin and Carboplatin, retaining Cisplatin’s anticancer activity while reducing toxicity similar to Carboplatin. After hydrolysis, Nedaplatin targets purines in DNA and forms cross-links t...

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Bibliographic Details
Main Authors: Kamil Szupryczyński, Beata Szefler
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomedicines
Subjects:
Nedaplatin
purine alkaloids
cancer treatment
Gibbs free energy change (ΔGr)
Density Functional Theory (DFT)
UV-Vis spectroscopy
Online Access:https://www.mdpi.com/2227-9059/13/7/1551
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