The effect of a barley-based food product in alleviating knee osteoarthritis discomfort symptoms in Egyptian female patients
Background/aim Osteoarthritis is a common joint condition that causes cartilage to erode. There are numerous conventional treatments available, including nonsteroidal anti-inflammatory medicines and pharmaceuticals containing glucosamine; however, taking them can result in serious side effects. The...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-12-01
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| Series: | Journal of the Arab Society for Medical Research |
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| Online Access: | https://journals.lww.com/10.4103/jasmr.jasmr_12_23 |
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| author | Suzanne Fouad Rasha Monir Fatma A. Ibrahim Ahmed M.S. Hussein Heba F. Shafei Aliaa El Gendy |
| author_facet | Suzanne Fouad Rasha Monir Fatma A. Ibrahim Ahmed M.S. Hussein Heba F. Shafei Aliaa El Gendy |
| author_sort | Suzanne Fouad |
| collection | DOAJ |
| description | Background/aim
Osteoarthritis is a common joint condition that causes cartilage to erode. There are numerous conventional treatments available, including nonsteroidal anti-inflammatory medicines and pharmaceuticals containing glucosamine; however, taking them can result in serious side effects. The aim of this study was to prepare barley-based food product enriched with ginger, curcumin, garlic powder, and onion powder and to evaluate the effect of consumption of the prepared macaroni for 2 months, in alleviating knee osteoarthritis discomfort symptoms in female patients complaining of grade 2–3 knee osteoarthritis.
Patients and methods
The present study enrolled 51 Egyptian middle age females patients with a mean age of 51±8.37 years, diagnosed with bilateral grade two to three knee osteoarthritis were recruited from the National Research Centre rheumatology and rehabilitation clinic. Anthropometric measurements and blood samples were collected after 8 weeks of daily barley based macaroni supplementation (75 grams raw). Serum levels of IL1β, IL4 and IL6 were measured using Elisa techniques, while Total Antioxidant Capacity, Malondialdehyde, and Glutathione S-transferase were measured by the colorimetric methods.
Results
Chemical composition analysis of the prepared barley-based macaroni demonstrated a decrease in total carbohydrate content and an increase in crude fiber, protein, and fat content compared with the control (semolina wheat-based macaroni); 100 grams of the prepared uncooked barley macaroni provided 342.46 Kcal. The reevaluation of the anthropometric parameters after 8 weeks of daily macaroni supplementation denoting improvement without statistical significance (P>0.05), and the clinical characteristics of knee joint osteoarthritis (Lequesne Index, WOMAC score, and Timed Up and Go test) significantly improved which meant less pain and stiffness. The serum pro-inflammatory cytokines IL1β and IL6 declined significantly and the serum anti-inflammatory cytokine IL4 raised significantly (P≤0.05), besides, barley based macaroni supplementation significantly improved the antioxidant status, which was achieved through the rise of serum Total Antioxidant Capacity and the decline of Malondialdehyde and Glutathione S-transferase activity (P≤0.05).
Conclusion
Barley-based prepared macaroni enriched with curcumin and ginger must be considered in alleviating the severity of knee OA symptoms to aid patients in getting their life back to near normal. |
| format | Article |
| id | doaj-art-1efa445e3d3142a88d0b38cb2e88dfcd |
| institution | Kabale University |
| issn | 1687-4293 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Arab Society for Medical Research |
| spelling | doaj-art-1efa445e3d3142a88d0b38cb2e88dfcd2025-01-20T04:24:30ZengWolters Kluwer Medknow PublicationsJournal of the Arab Society for Medical Research1687-42932023-12-0118218219010.4103/jasmr.jasmr_12_23The effect of a barley-based food product in alleviating knee osteoarthritis discomfort symptoms in Egyptian female patientsSuzanne FouadRasha MonirFatma A. IbrahimAhmed M.S. HusseinHeba F. ShafeiAliaa El GendyBackground/aim Osteoarthritis is a common joint condition that causes cartilage to erode. There are numerous conventional treatments available, including nonsteroidal anti-inflammatory medicines and pharmaceuticals containing glucosamine; however, taking them can result in serious side effects. The aim of this study was to prepare barley-based food product enriched with ginger, curcumin, garlic powder, and onion powder and to evaluate the effect of consumption of the prepared macaroni for 2 months, in alleviating knee osteoarthritis discomfort symptoms in female patients complaining of grade 2–3 knee osteoarthritis. Patients and methods The present study enrolled 51 Egyptian middle age females patients with a mean age of 51±8.37 years, diagnosed with bilateral grade two to three knee osteoarthritis were recruited from the National Research Centre rheumatology and rehabilitation clinic. Anthropometric measurements and blood samples were collected after 8 weeks of daily barley based macaroni supplementation (75 grams raw). Serum levels of IL1β, IL4 and IL6 were measured using Elisa techniques, while Total Antioxidant Capacity, Malondialdehyde, and Glutathione S-transferase were measured by the colorimetric methods. Results Chemical composition analysis of the prepared barley-based macaroni demonstrated a decrease in total carbohydrate content and an increase in crude fiber, protein, and fat content compared with the control (semolina wheat-based macaroni); 100 grams of the prepared uncooked barley macaroni provided 342.46 Kcal. The reevaluation of the anthropometric parameters after 8 weeks of daily macaroni supplementation denoting improvement without statistical significance (P>0.05), and the clinical characteristics of knee joint osteoarthritis (Lequesne Index, WOMAC score, and Timed Up and Go test) significantly improved which meant less pain and stiffness. The serum pro-inflammatory cytokines IL1β and IL6 declined significantly and the serum anti-inflammatory cytokine IL4 raised significantly (P≤0.05), besides, barley based macaroni supplementation significantly improved the antioxidant status, which was achieved through the rise of serum Total Antioxidant Capacity and the decline of Malondialdehyde and Glutathione S-transferase activity (P≤0.05). Conclusion Barley-based prepared macaroni enriched with curcumin and ginger must be considered in alleviating the severity of knee OA symptoms to aid patients in getting their life back to near normal.https://journals.lww.com/10.4103/jasmr.jasmr_12_23barleydiet therapyknee osteoarthritismacaronipasting properties |
| spellingShingle | Suzanne Fouad Rasha Monir Fatma A. Ibrahim Ahmed M.S. Hussein Heba F. Shafei Aliaa El Gendy The effect of a barley-based food product in alleviating knee osteoarthritis discomfort symptoms in Egyptian female patients Journal of the Arab Society for Medical Research barley diet therapy knee osteoarthritis macaroni pasting properties |
| title | The effect of a barley-based food product in alleviating knee osteoarthritis discomfort symptoms in Egyptian female patients |
| title_full | The effect of a barley-based food product in alleviating knee osteoarthritis discomfort symptoms in Egyptian female patients |
| title_fullStr | The effect of a barley-based food product in alleviating knee osteoarthritis discomfort symptoms in Egyptian female patients |
| title_full_unstemmed | The effect of a barley-based food product in alleviating knee osteoarthritis discomfort symptoms in Egyptian female patients |
| title_short | The effect of a barley-based food product in alleviating knee osteoarthritis discomfort symptoms in Egyptian female patients |
| title_sort | effect of a barley based food product in alleviating knee osteoarthritis discomfort symptoms in egyptian female patients |
| topic | barley diet therapy knee osteoarthritis macaroni pasting properties |
| url | https://journals.lww.com/10.4103/jasmr.jasmr_12_23 |
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