Effects of Microsatellite Instability on the Clinical and Pathological Characteristics of Colon Cancer and the Diagnostic Accuracy of Preoperative Abdominal CT Scans
<b>Background</b>: Microsatellite-stable (MSS) and microsatellite-instable (MSI) colon cancer (CC) cases have different characteristics. These characteristics may impact the accuracy of abdominal computed tomography (CT) scan examinations in MSI CC. <b>Methods</b>: A retrospe...
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2025-01-01
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| author | Rıdvan Yavuz Orhan Aras Hüseyin Çiyiltepe Onur İlkay Dinçer Ahmet Şükrü Alparslan Tebessüm Çakır |
| author_facet | Rıdvan Yavuz Orhan Aras Hüseyin Çiyiltepe Onur İlkay Dinçer Ahmet Şükrü Alparslan Tebessüm Çakır |
| author_sort | Rıdvan Yavuz |
| collection | DOAJ |
| description | <b>Background</b>: Microsatellite-stable (MSS) and microsatellite-instable (MSI) colon cancer (CC) cases have different characteristics. These characteristics may impact the accuracy of abdominal computed tomography (CT) scan examinations in MSI CC. <b>Methods</b>: A retrospective analysis was conducted to examine the effects of MSI CC on patients’ clinical and tumor characteristics. We determined the accuracy of radiological T and N staging compared to pathological T and N staging in CC patients and evaluated the influence of tumor- and patient-related factors on this accuracy. <b>Results</b>: A total of 131 CC patients who had undergone surgical resection were analyzed. Mismatch repair-deficient (dMMR) CC was predominantly found in the right hemicolon (<i>p</i> = 0.023); it was more likely to exhibit moderate (80.8%) or low-grade differentiation (<i>p</i> = 0.01) and had higher rates of mucinous differentiation (<i>p</i> = 0.001). The median neutrophil and platelet counts and C-reactive protein (CRP) levels at diagnosis were significantly higher in patients with dMMR CC (<i>p</i> = 0.022, <i>p</i> = 0.022, and <i>p</i> = 0.018). The depth of invasion influenced the CRP levels in dMMR CC cases (<i>p</i> = 0.015). The abdominal CT exam was accurate regarding the depth of colonic wall invasion in 58.1% and 38.5% of patients with mismatch repair-proficient (pMMR) and dMMR CC, respectively. The assessment of lymph node invasion was accurate in 44.8% of those with pMMR and 50.0% of those with dMMR CC. There was no significant difference in the accuracy in predicting the T and N statuses between the two groups. The accuracy in the determination of the T and N statuses was not affected by the parameters examined. <b>Conclusions</b>: dMMR CC has specific characteristic features. MSI does not affect the accuracy of preoperative abdominal CT. |
| format | Article |
| id | doaj-art-1ee91584885645d2b7fc62d60996bac9 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
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| series | Diagnostics |
| spelling | doaj-art-1ee91584885645d2b7fc62d60996bac92025-01-24T13:29:03ZengMDPI AGDiagnostics2075-44182025-01-0115219010.3390/diagnostics15020190Effects of Microsatellite Instability on the Clinical and Pathological Characteristics of Colon Cancer and the Diagnostic Accuracy of Preoperative Abdominal CT ScansRıdvan Yavuz0Orhan Aras1Hüseyin Çiyiltepe2Onur İlkay Dinçer3Ahmet Şükrü Alparslan4Tebessüm Çakır5Gastroenterology Surgery Department, Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., Muratpaşa 07100, Antalya, TurkeyGastroenterology Surgery Department, Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., Muratpaşa 07100, Antalya, TurkeyGastroenterology Surgery Department, Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., Muratpaşa 07100, Antalya, TurkeyGastroenterology Surgery Department, Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., Muratpaşa 07100, Antalya, TurkeyRadiology Department, Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., Muratpaşa 07100, Antalya, TurkeyGastroenterology Surgery Department, Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., Muratpaşa 07100, Antalya, Turkey<b>Background</b>: Microsatellite-stable (MSS) and microsatellite-instable (MSI) colon cancer (CC) cases have different characteristics. These characteristics may impact the accuracy of abdominal computed tomography (CT) scan examinations in MSI CC. <b>Methods</b>: A retrospective analysis was conducted to examine the effects of MSI CC on patients’ clinical and tumor characteristics. We determined the accuracy of radiological T and N staging compared to pathological T and N staging in CC patients and evaluated the influence of tumor- and patient-related factors on this accuracy. <b>Results</b>: A total of 131 CC patients who had undergone surgical resection were analyzed. Mismatch repair-deficient (dMMR) CC was predominantly found in the right hemicolon (<i>p</i> = 0.023); it was more likely to exhibit moderate (80.8%) or low-grade differentiation (<i>p</i> = 0.01) and had higher rates of mucinous differentiation (<i>p</i> = 0.001). The median neutrophil and platelet counts and C-reactive protein (CRP) levels at diagnosis were significantly higher in patients with dMMR CC (<i>p</i> = 0.022, <i>p</i> = 0.022, and <i>p</i> = 0.018). The depth of invasion influenced the CRP levels in dMMR CC cases (<i>p</i> = 0.015). The abdominal CT exam was accurate regarding the depth of colonic wall invasion in 58.1% and 38.5% of patients with mismatch repair-proficient (pMMR) and dMMR CC, respectively. The assessment of lymph node invasion was accurate in 44.8% of those with pMMR and 50.0% of those with dMMR CC. There was no significant difference in the accuracy in predicting the T and N statuses between the two groups. The accuracy in the determination of the T and N statuses was not affected by the parameters examined. <b>Conclusions</b>: dMMR CC has specific characteristic features. MSI does not affect the accuracy of preoperative abdominal CT.https://www.mdpi.com/2075-4418/15/2/190colon cancermicrosatellite instabilitycomputed tomographypreoperative stagingsystemic inflammatory markersC-reactive protein |
| spellingShingle | Rıdvan Yavuz Orhan Aras Hüseyin Çiyiltepe Onur İlkay Dinçer Ahmet Şükrü Alparslan Tebessüm Çakır Effects of Microsatellite Instability on the Clinical and Pathological Characteristics of Colon Cancer and the Diagnostic Accuracy of Preoperative Abdominal CT Scans Diagnostics colon cancer microsatellite instability computed tomography preoperative staging systemic inflammatory markers C-reactive protein |
| title | Effects of Microsatellite Instability on the Clinical and Pathological Characteristics of Colon Cancer and the Diagnostic Accuracy of Preoperative Abdominal CT Scans |
| title_full | Effects of Microsatellite Instability on the Clinical and Pathological Characteristics of Colon Cancer and the Diagnostic Accuracy of Preoperative Abdominal CT Scans |
| title_fullStr | Effects of Microsatellite Instability on the Clinical and Pathological Characteristics of Colon Cancer and the Diagnostic Accuracy of Preoperative Abdominal CT Scans |
| title_full_unstemmed | Effects of Microsatellite Instability on the Clinical and Pathological Characteristics of Colon Cancer and the Diagnostic Accuracy of Preoperative Abdominal CT Scans |
| title_short | Effects of Microsatellite Instability on the Clinical and Pathological Characteristics of Colon Cancer and the Diagnostic Accuracy of Preoperative Abdominal CT Scans |
| title_sort | effects of microsatellite instability on the clinical and pathological characteristics of colon cancer and the diagnostic accuracy of preoperative abdominal ct scans |
| topic | colon cancer microsatellite instability computed tomography preoperative staging systemic inflammatory markers C-reactive protein |
| url | https://www.mdpi.com/2075-4418/15/2/190 |
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