Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival

Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival

Abstract One hallmark of cancer is the upregulation and dependency on glucose metabolism to fuel macromolecule biosynthesis and rapid proliferation. Despite significant pre-clinical effort to exploit this pathway, additional mechanistic insights are necessary to prioritize the diversity of metabolic...

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Main Authors: Monika Komza, Jesminara Khatun, Jesse D. Gelles, Andrew P. Trotta, Ioana Abraham-Enachescu, Juan Henao, Ahmed Elsaadi, Andriana G. Kotini, Cara Clementelli, JoAnn Arandela, Sebastian El Ghaity-Beckley, Agneesh Barua, Yiyang Chen, Mirela Berisa, Bridget K. Marcellino, Eirini P. Papapetrou, Masha V. Poyurovsky, Jerry Edward Chipuk
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cell Communication and Signaling
Subjects:
Adaptations
Bioenergetics
Cancer
Chemotherapy
Glucose
Leukemia
Online Access:https://doi.org/10.1186/s12964-025-02044-y
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https://doi.org/10.1186/s12964-025-02044-y

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