Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis

Epigenetic age acceleration and methylation differences in IgG4-related cholangitis and primary sclerosing cholangitis

Abstract Background IgG4-related cholangitis (IgG4-SC) and primary sclerosing cholangitis (PSC) are chronic fibro-inflammatory hepatobiliary conditions, with genetic, environmental, and immunologic risk factors, in which epigenetic alterations may provide insights into pathophysiology and novel biom...

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Bibliographic Details
Main Authors: Alexandra Noble, Rodrigo Motta, Silvia Cabras, Belen Moron Flores, Jan Nowak, Aleksandra Glapa-Nowak, Alessandra Geremia, Jack Satsangi, Emma Culver
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Clinical Epigenetics
Subjects:
PSC
IgG4-RD
DNA methylation
Infinium Methylation EPIC arrays
HLA
Epigenetic clock
Online Access:https://doi.org/10.1186/s13148-024-01803-x
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https://doi.org/10.1186/s13148-024-01803-x

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