Smad4 and TGFβ1 dependent gene expression signatures in conditional intestinal adenoma, organoids and colorectal cancer

Smad4 and TGFβ1 dependent gene expression signatures in conditional intestinal adenoma, organoids and colorectal cancer

Abstract TGF-β ligands suppress growth yet can paradoxically and potently promote cancer invasion and metastasis depending on downstream pathway mutational context, such as loss of Mothers against decapentaplegic homolog 4 (Smad4). Here, we characterised phenotypes and associated gene expression sig...

Full description

Saved in:
Bibliographic Details
Main Authors: Mirvat Surakhy, Julia Matheson, David J. Barnes, Emma J. Carter, Jennifer Hughes, Claudia Bühnemann, Sabina Sanegre, Hans Morreau, Paul Metz, Charlotte J. Imianowski, Andrew Bassim Hassan
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Smad4
Apc
Intestine
Adenoma
TGF-β1
Id1
Online Access:https://doi.org/10.1038/s41598-025-00908-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-00908-4

Similar Items