Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress

Gallic acid protects intervertebral disc cells from ferroptosis and alleviates intervertebral disc degeneration by regulating key factors of oxidative stress

BackgroundIntervertebral disc degeneration (IDD) is a chronic degenerative disease and one of the main causes of low back pain (LBP). Currently, there is no effective treatment. Ferroptosis is a cell-regulated process that depends on iron deposition and lipid peroxidation. Inhibiting ferroptosis in...

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Bibliographic Details
Main Authors: Zaishi Zhu, Zeling Huang, Chaofeng Zhang, Bo Xu, Hua Chen, Shuai Pei, Baofei Zhang, Lishi Jie, Xiaoqing Shi, Yujiang Liu, Yuwei Li, Xiaofeng Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
ferroptosis
intervertebral disc degeneration
oxidative stress
nucleus pulposus
gallic acid
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1501725/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1501725/full

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