Structure-Function of Falcipains: Malarial Cysteine Proteases
Evidence indicates that cysteine proteases play essential role in malaria parasites; therefore an obvious area of investigation is the inhibition of these enzymes to treat malaria. Studies with cysteine protease inhibitors and manipulating cysteine proteases genes have suggested a role for cysteine...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2012/345195 |
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| _version_ | 1832550336716341248 |
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| author | Kailash C. Pandey Rajnikant Dixit |
| author_facet | Kailash C. Pandey Rajnikant Dixit |
| author_sort | Kailash C. Pandey |
| collection | DOAJ |
| description | Evidence indicates that cysteine proteases play essential role in malaria parasites; therefore an obvious area of investigation is the inhibition of these enzymes to treat malaria. Studies with cysteine protease inhibitors and manipulating cysteine proteases genes have suggested a role for cysteine proteases in hemoglobin hydrolysis. The best characterized Plasmodium cysteine proteases are falcipains, which are papain family enzymes. Falcipain-2 and falcipain-3 are major hemoglobinases of P. falciparum. Structural and functional analysis of falcipains showed that they have unique domains including a refolding domain and a hemoglobin binding domain. Overall, the complexes of falcipain-2 and falcipain-3 with small and macromolecular inhibitors provide structural insight to facilitate the design or modification of effective drug treatment against malaria. Drug development targeting falcipains should be aided by a strong foundation of biochemical and structural studies. |
| format | Article |
| id | doaj-art-1e898ce8e69c452bbf88e3287dc8a9ee |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-1e898ce8e69c452bbf88e3287dc8a9ee2025-02-03T06:06:57ZengWileyJournal of Tropical Medicine1687-96861687-96942012-01-01201210.1155/2012/345195345195Structure-Function of Falcipains: Malarial Cysteine ProteasesKailash C. Pandey0Rajnikant Dixit1Host-Parasite Interaction Biology Group, National Institute of Malaria Research, Indian Council of Medical Research, Sector-8, Dwarka, New Delhi 110 077, IndiaHost-Parasite Interaction Biology Group, National Institute of Malaria Research, Indian Council of Medical Research, Sector-8, Dwarka, New Delhi 110 077, IndiaEvidence indicates that cysteine proteases play essential role in malaria parasites; therefore an obvious area of investigation is the inhibition of these enzymes to treat malaria. Studies with cysteine protease inhibitors and manipulating cysteine proteases genes have suggested a role for cysteine proteases in hemoglobin hydrolysis. The best characterized Plasmodium cysteine proteases are falcipains, which are papain family enzymes. Falcipain-2 and falcipain-3 are major hemoglobinases of P. falciparum. Structural and functional analysis of falcipains showed that they have unique domains including a refolding domain and a hemoglobin binding domain. Overall, the complexes of falcipain-2 and falcipain-3 with small and macromolecular inhibitors provide structural insight to facilitate the design or modification of effective drug treatment against malaria. Drug development targeting falcipains should be aided by a strong foundation of biochemical and structural studies.http://dx.doi.org/10.1155/2012/345195 |
| spellingShingle | Kailash C. Pandey Rajnikant Dixit Structure-Function of Falcipains: Malarial Cysteine Proteases Journal of Tropical Medicine |
| title | Structure-Function of Falcipains: Malarial Cysteine Proteases |
| title_full | Structure-Function of Falcipains: Malarial Cysteine Proteases |
| title_fullStr | Structure-Function of Falcipains: Malarial Cysteine Proteases |
| title_full_unstemmed | Structure-Function of Falcipains: Malarial Cysteine Proteases |
| title_short | Structure-Function of Falcipains: Malarial Cysteine Proteases |
| title_sort | structure function of falcipains malarial cysteine proteases |
| url | http://dx.doi.org/10.1155/2012/345195 |
| work_keys_str_mv | AT kailashcpandey structurefunctionoffalcipainsmalarialcysteineproteases AT rajnikantdixit structurefunctionoffalcipainsmalarialcysteineproteases |