PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia
Peroxisome proliferator-activated receptor γ (PPAR-γ) is a ligand-activated nuclear receptor that regulates the transcription of various genes. PPAR-γ plays roles in lipid homeostasis, sebocyte maturation, and peroxisome biogenesis and has shown anti-inflammatory effects. PPAR-γ is highly expressed...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | PPAR Research |
| Online Access: | http://dx.doi.org/10.1155/2017/2501248 |
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| author | Sarawin Harnchoowong Poonkiat Suchonwanit |
| author_facet | Sarawin Harnchoowong Poonkiat Suchonwanit |
| author_sort | Sarawin Harnchoowong |
| collection | DOAJ |
| description | Peroxisome proliferator-activated receptor γ (PPAR-γ) is a ligand-activated nuclear receptor that regulates the transcription of various genes. PPAR-γ plays roles in lipid homeostasis, sebocyte maturation, and peroxisome biogenesis and has shown anti-inflammatory effects. PPAR-γ is highly expressed in human sebaceous glands. Disruption of PPAR-γ is believed to be one of the mechanisms of primary cicatricial alopecia (PCA) pathogenesis, causing pilosebaceous dysfunction leading to follicular inflammation. In this review article, we discuss the pathogenesis of PCA with a focus on PPAR-γ involvement in pathogenesis of lichen planopilaris (LPP), the most common lymphocytic form of PCA. We also discuss clinical trials utilizing PPAR-agonists in PCA treatment. |
| format | Article |
| id | doaj-art-1e85aae362ec408191be5f721ba63f30 |
| institution | Kabale University |
| issn | 1687-4757 1687-4765 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | PPAR Research |
| spelling | doaj-art-1e85aae362ec408191be5f721ba63f302025-02-03T01:26:22ZengWileyPPAR Research1687-47571687-47652017-01-01201710.1155/2017/25012482501248PPAR-γ Agonists and Their Role in Primary Cicatricial AlopeciaSarawin Harnchoowong0Poonkiat Suchonwanit1Division of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDivision of Dermatology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, ThailandPeroxisome proliferator-activated receptor γ (PPAR-γ) is a ligand-activated nuclear receptor that regulates the transcription of various genes. PPAR-γ plays roles in lipid homeostasis, sebocyte maturation, and peroxisome biogenesis and has shown anti-inflammatory effects. PPAR-γ is highly expressed in human sebaceous glands. Disruption of PPAR-γ is believed to be one of the mechanisms of primary cicatricial alopecia (PCA) pathogenesis, causing pilosebaceous dysfunction leading to follicular inflammation. In this review article, we discuss the pathogenesis of PCA with a focus on PPAR-γ involvement in pathogenesis of lichen planopilaris (LPP), the most common lymphocytic form of PCA. We also discuss clinical trials utilizing PPAR-agonists in PCA treatment.http://dx.doi.org/10.1155/2017/2501248 |
| spellingShingle | Sarawin Harnchoowong Poonkiat Suchonwanit PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia PPAR Research |
| title | PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia |
| title_full | PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia |
| title_fullStr | PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia |
| title_full_unstemmed | PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia |
| title_short | PPAR-γ Agonists and Their Role in Primary Cicatricial Alopecia |
| title_sort | ppar γ agonists and their role in primary cicatricial alopecia |
| url | http://dx.doi.org/10.1155/2017/2501248 |
| work_keys_str_mv | AT sarawinharnchoowong ppargagonistsandtheirroleinprimarycicatricialalopecia AT poonkiatsuchonwanit ppargagonistsandtheirroleinprimarycicatricialalopecia |