USP5 inhibition via bone marrow-targeted engineered exosomes for myeloproliferative neoplasms therapy

USP5 inhibition via bone marrow-targeted engineered exosomes for myeloproliferative neoplasms therapy

Abstract Myeloproliferative neoplasms (MPNs) are challenging to treat due to the complex bone marrow (BM) microenvironment and lack of curative therapies. Current treatments fail to eliminate malignant clones and face issues like drug resistance. This study addressed these challenges by identifying...

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Bibliographic Details
Main Authors: Wenjun Wang, Yufeng Jiang, Donglei Zhang, Xian Zhang, Qian Liang, Jun Shi, Yuan Zhou, Fuling Zhou
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Subjects:
Myeloproliferative neoplasms
Mesenchymal stem cells
Deubiquitinating enzyme
Bone marrow targeting
Online Access:https://doi.org/10.1186/s12951-025-03588-4
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