RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells

RET Inhibitor SPP86 Triggers Apoptosis and Activates the DNA Damage Response Through the Suppression of Autophagy and the PI3K/AKT Signaling Pathway in Melanoma Cells

Yuli Zhang,1,2 Haidong Liu,1 Kun Wang,3 Juan Zheng,4 Hong Luan,1 Ming Xin5 1Department of Dermatology, Liaocheng People’s Hospital, Liaocheng, Shandong, People’s Republic of China; 2Department of Endocrinology, The Second Hospital of Shandong University, Jinan, Shandong, People’s Republic of China;...

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Bibliographic Details
Main Authors: Zhang Y, Liu H, Wang K, Zheng J, Luan H, Xin M
Format: Article
Language:English
Published: Dove Medical Press 2025-01-01
Series:Drug Design, Development and Therapy
Subjects:
melanoma
spp86
autophagy
dna damage
apoptosis
pi3k/akt
Online Access:https://www.dovepress.com/ret-inhibitor-spp86-triggers-apoptosis-and-activates-the-dna-damage-re-peer-reviewed-fulltext-article-DDDT
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