Efficacy and Tolerability of the Association of Sibutramine and Orlistat for Six Months in Overweight and Obese Patients
Objective. To assess the efficacy and tolerability of the association sibutramine (10–20 mg/day) and orlistat (120 mg 2-3 times a day) in the treatment of obesity in a six-month open trial. Methods. 446 overweight and obese patients who sought treatment for obesity in a private clinic were assessed...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2010/602537 |
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| author | Alfredo Halpern Renata B. Pepe Ana Paola Monegaglia Mônica Beyruti Maria Edna de Melo Marcio C. Mancini |
| author_facet | Alfredo Halpern Renata B. Pepe Ana Paola Monegaglia Mônica Beyruti Maria Edna de Melo Marcio C. Mancini |
| author_sort | Alfredo Halpern |
| collection | DOAJ |
| description | Objective. To assess the efficacy and tolerability of the association sibutramine (10–20 mg/day) and orlistat (120 mg 2-3 times a day) in the treatment of obesity in a six-month open trial. Methods. 446 overweight and obese patients who sought treatment for obesity in a private clinic were assessed every 2 weeks during a period of 3 and 6 months. Results. After 3 months, the mean weight loss was 10.5 kg (−9.8% of the initial weight, 𝑛=263), and after 6 months, the mean weight loss was 13.9 kg (−12.8% of the initial weight, 𝑛=97). The tolerability of such association was quite acceptable and coherent with the action mechanism of each component. Conclusions. The association of orlistat and sibutramine is quite efficient and it seems to promote a higher rate of weight loss than that reported in clinical studies performed with each drug separately. |
| format | Article |
| id | doaj-art-1e56c053af7d4a04bce71fabb8d15d71 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-1e56c053af7d4a04bce71fabb8d15d712025-02-03T05:49:37ZengWileyJournal of Obesity2090-07082090-07162010-01-01201010.1155/2010/602537602537Efficacy and Tolerability of the Association of Sibutramine and Orlistat for Six Months in Overweight and Obese PatientsAlfredo Halpern0Renata B. Pepe1Ana Paola Monegaglia2Mônica Beyruti3Maria Edna de Melo4Marcio C. Mancini5Group of Obesity & Metabolic Syndrome, Endocrinology Service, Hospital das Clínicas, Faculty of Medicine, University of Sao Paulo, 05410-000 São Paulo, BrazilDepartment of Nutrition and Dietitian, Clínica Alfredo Halpern, 05410-000 São Paulo, BrazilDepartment of Nutrition and Dietitian, Clínica Alfredo Halpern, 05410-000 São Paulo, BrazilDepartment of Nutrition and Dietitian, Clínica Alfredo Halpern, 05410-000 São Paulo, BrazilGroup of Obesity & Metabolic Syndrome, Endocrinology Service, Hospital das Clínicas, Faculty of Medicine, University of Sao Paulo, 05410-000 São Paulo, BrazilGroup of Obesity & Metabolic Syndrome, Endocrinology Service, Hospital das Clínicas, Faculty of Medicine, University of Sao Paulo, 05410-000 São Paulo, BrazilObjective. To assess the efficacy and tolerability of the association sibutramine (10–20 mg/day) and orlistat (120 mg 2-3 times a day) in the treatment of obesity in a six-month open trial. Methods. 446 overweight and obese patients who sought treatment for obesity in a private clinic were assessed every 2 weeks during a period of 3 and 6 months. Results. After 3 months, the mean weight loss was 10.5 kg (−9.8% of the initial weight, 𝑛=263), and after 6 months, the mean weight loss was 13.9 kg (−12.8% of the initial weight, 𝑛=97). The tolerability of such association was quite acceptable and coherent with the action mechanism of each component. Conclusions. The association of orlistat and sibutramine is quite efficient and it seems to promote a higher rate of weight loss than that reported in clinical studies performed with each drug separately.http://dx.doi.org/10.1155/2010/602537 |
| spellingShingle | Alfredo Halpern Renata B. Pepe Ana Paola Monegaglia Mônica Beyruti Maria Edna de Melo Marcio C. Mancini Efficacy and Tolerability of the Association of Sibutramine and Orlistat for Six Months in Overweight and Obese Patients Journal of Obesity |
| title | Efficacy and Tolerability of the Association of Sibutramine and
Orlistat for Six Months in Overweight and Obese Patients |
| title_full | Efficacy and Tolerability of the Association of Sibutramine and
Orlistat for Six Months in Overweight and Obese Patients |
| title_fullStr | Efficacy and Tolerability of the Association of Sibutramine and
Orlistat for Six Months in Overweight and Obese Patients |
| title_full_unstemmed | Efficacy and Tolerability of the Association of Sibutramine and
Orlistat for Six Months in Overweight and Obese Patients |
| title_short | Efficacy and Tolerability of the Association of Sibutramine and
Orlistat for Six Months in Overweight and Obese Patients |
| title_sort | efficacy and tolerability of the association of sibutramine and orlistat for six months in overweight and obese patients |
| url | http://dx.doi.org/10.1155/2010/602537 |
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