Solid-State FTIR Spectroscopic Study of Two Binary Mixtures: Cefepime-Metronidazole and Cefoperazone-Sulbactam
The structural information of the pharmaceuticals and insights on the modes of molecular interactions are very important aspects in drug development. In this work, two cephalosporins and antimicrobial combinations, cefepime-metronidazole and cefoperazone-sulbactam, were studied in the solid state us...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Spectroscopy |
| Online Access: | http://dx.doi.org/10.1155/2017/5673214 |
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| author | Hassan Refat H. Ali Ramadan Ali Hany A. Batakoushy Sayed M. Derayea |
| author_facet | Hassan Refat H. Ali Ramadan Ali Hany A. Batakoushy Sayed M. Derayea |
| author_sort | Hassan Refat H. Ali |
| collection | DOAJ |
| description | The structural information of the pharmaceuticals and insights on the modes of molecular interactions are very important aspects in drug development. In this work, two cephalosporins and antimicrobial combinations, cefepime-metronidazole and cefoperazone-sulbactam, were studied in the solid state using FTIR spectroscopy for the first time. Quantitation of the studied drugs and their binary mixtures was performed by integrating the peak areas of the characteristic well-resolved bands: υ (C=O) band at 1773 cm−1 for cefepime and ring torsion band at 826 cm−1 for metronidazole and υ (C=O) band at 1715 cm−1 for cefoperazone and ring torsion band at 1124 cm−1 for sulbactam. The results of this work were compared with the relevant spectrophotometric reported methods. This study provides data that can be used for the preparative process monitoring of the studied drugs in various dosage forms. |
| format | Article |
| id | doaj-art-1e2c96dc9d004b688778836b7e89e391 |
| institution | Kabale University |
| issn | 2314-4920 2314-4939 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Spectroscopy |
| spelling | doaj-art-1e2c96dc9d004b688778836b7e89e3912025-02-03T01:32:41ZengWileyJournal of Spectroscopy2314-49202314-49392017-01-01201710.1155/2017/56732145673214Solid-State FTIR Spectroscopic Study of Two Binary Mixtures: Cefepime-Metronidazole and Cefoperazone-SulbactamHassan Refat H. Ali0Ramadan Ali1Hany A. Batakoushy2Sayed M. Derayea3Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Assiut University, Assiut 71526, EgyptDepartment of Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, EgyptDepartment of Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut 71524, EgyptDepartment of Analytical Chemistry, Faculty of Pharmacy, Minia University, Minia, EgyptThe structural information of the pharmaceuticals and insights on the modes of molecular interactions are very important aspects in drug development. In this work, two cephalosporins and antimicrobial combinations, cefepime-metronidazole and cefoperazone-sulbactam, were studied in the solid state using FTIR spectroscopy for the first time. Quantitation of the studied drugs and their binary mixtures was performed by integrating the peak areas of the characteristic well-resolved bands: υ (C=O) band at 1773 cm−1 for cefepime and ring torsion band at 826 cm−1 for metronidazole and υ (C=O) band at 1715 cm−1 for cefoperazone and ring torsion band at 1124 cm−1 for sulbactam. The results of this work were compared with the relevant spectrophotometric reported methods. This study provides data that can be used for the preparative process monitoring of the studied drugs in various dosage forms.http://dx.doi.org/10.1155/2017/5673214 |
| spellingShingle | Hassan Refat H. Ali Ramadan Ali Hany A. Batakoushy Sayed M. Derayea Solid-State FTIR Spectroscopic Study of Two Binary Mixtures: Cefepime-Metronidazole and Cefoperazone-Sulbactam Journal of Spectroscopy |
| title | Solid-State FTIR Spectroscopic Study of Two Binary Mixtures: Cefepime-Metronidazole and Cefoperazone-Sulbactam |
| title_full | Solid-State FTIR Spectroscopic Study of Two Binary Mixtures: Cefepime-Metronidazole and Cefoperazone-Sulbactam |
| title_fullStr | Solid-State FTIR Spectroscopic Study of Two Binary Mixtures: Cefepime-Metronidazole and Cefoperazone-Sulbactam |
| title_full_unstemmed | Solid-State FTIR Spectroscopic Study of Two Binary Mixtures: Cefepime-Metronidazole and Cefoperazone-Sulbactam |
| title_short | Solid-State FTIR Spectroscopic Study of Two Binary Mixtures: Cefepime-Metronidazole and Cefoperazone-Sulbactam |
| title_sort | solid state ftir spectroscopic study of two binary mixtures cefepime metronidazole and cefoperazone sulbactam |
| url | http://dx.doi.org/10.1155/2017/5673214 |
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