VRK1 promotes epithelial-mesenchymal transition in hepatocellular carcinoma mediated by SNAI1 via phosphorylating CHD1L

Abstract Vaccinia-related kinase 1 (VRK1) is involved in numerous cellular processes, including DNA repair, cell cycle and cell proliferation. However, its roles and molecular mechanism underlying the progression of hepatocellular carcinoma (HCC) are yet largely unexplored. Here, we demonstrated tha...

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Main Authors: Jing Li, Zan Song, Xue Dong, Leilei Li, Xinyu Gu, Kailing Zhang, Zhicheng Zhang, Yu Li, Zhili Fan, Hao Dong, Ying Liu, Mengfei Liu, Huiqing Zhang, Wu Liu, Tao Zhang
Format: Article
Language:English
Published: Nature Publishing Group 2025-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07641-w
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