Hesperidin loaded bilosomes mitigate the nephrotoxicity induced by methotrexate; biochemical and molecular in vivo investigations

Hesperidin loaded bilosomes mitigate the nephrotoxicity induced by methotrexate; biochemical and molecular in vivo investigations

Abstract Background Drugs, chemicals, and poisons may damage kidneys and cause chronic renal disease. About 20% of community and hospital acute renal failures are drug-related. Objectives Hesperidin-loaded bilosomes (HES-BS) nanoformula was tested for nephroprotection against methotrexate (MTX)-indu...

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Bibliographic Details
Main Authors: Shiemaa H. Mahmoud, Walaa A. Moselhy, Ahmed F. Azmy, Fatma I. Abo El-Ela
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Nephrology
Subjects:
Hesperidin
Bilosomes
Nephrotoxicity
Nrf2
Keap1
Bcl2
Online Access:https://doi.org/10.1186/s12882-025-04328-4
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