Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research

Impact of age-related changes in buccal epithelial cells on pediatric epigenetic biomarker research

Abstract Cheek swabs, heterogeneous samples consisting primarily of buccal epithelial cells, are widely used in pediatric DNA methylation studies and biomarker creation. However, the decrease in buccal proportion with age in adults remains unexamined in childhood. We analyzed cheek swabs from 4626 t...

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Main Authors: Sarah M. Merrill, Chaini Konwar, Fizza Fatima, Kristy Dever, Julia L. MacIsaac, Nicole Letourneau, Gerald F. Giesbrecht, Deborah Dewey, Gillian England-Mason, Candace R. Lewis, Dennis Wang, Ai Ling Teh, Michael J. Meaney, Andrea Gonzalez, Jennie G. Noll, Carolina De Weerth, Nicole R. Bush, Kieran J. O’Donnell, S. Evelyn Stewart, Michael S. Kobor
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-55909-8
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https://doi.org/10.1038/s41467-025-55909-8

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