Strain-Divergent m6A Landscapes Modulate Nipah Virus Replication and METTL3 Inhibition Attenuates Virulence

Strain-Divergent m6A Landscapes Modulate Nipah Virus Replication and METTL3 Inhibition Attenuates Virulence

Nipah virus (NiV), a highly lethal zoonotic paramyxovirus, displays strain-specific pathogenicity, yet the molecular basis for this divergence remains elusive. Here, we identify N6-methyladenosine (m6A) modification as a pivotal regulator of NiV replication. Higher m6A methylation levels on viral ge...

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Bibliographic Details
Main Authors: Ting Luo, Zhen Chen, Fang Zhang, Haibin Liu, Fang Huang, Xueyan Zhang, Jiangpeng Feng, Shuang Ding, Lishi Liu, Wuxiang Guan, Aiping Zeng, Haojie Hao
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Viruses
Subjects:
Nipah virus (NiV)
N6-methyladenosine (m6A)
virus pathogenicity
antiviral strategy
METTL3 inhibitor
Online Access:https://www.mdpi.com/1999-4915/17/6/831
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