An Fe(III)-covalent organic framework (COF)–sorafenib nanoplatform induces chemo-ferroptosis for enhanced hepatocellular carcinoma immunotherapy

An Fe(III)-covalent organic framework (COF)–sorafenib nanoplatform induces chemo-ferroptosis for enhanced hepatocellular carcinoma immunotherapy

Chemoresistance remains a tremendous challenge in the clinical treatment of hepatocellular carcinoma (HCC). However, the induction of ferroptosis, a form of regulated cell death, could overcome chemoresistance and improve treatment outcomes for HCC patients. In this study, we constructed a covalent...

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Main Authors: Binglong Bai, Zihao Zheng, Bingzi Zhu, Jianlin Wu, Yizhou Xu, Xihao Zhong, Wenhai Deng, Xiang Wang, Shengsheng Zhao, Tao You, Yingpeng Huang, Weijian Sun, Xian Shen, Xufeng Lu
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Materials Today Bio
Subjects:
Covalent organic framework (COF)
Sorafenib
Chemo-ferroptosis
Hepatocellular carcinoma (HCC)
Programmed death receptor-1 (PD-1)
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425007057
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