Lipopolysaccharide Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac Surgery
Objectives. The changes in the serum levels of lipopolysaccharide binding protein (LBP) and sCD14 during cardiac surgery were followed in this study. Design. Thirty-four patients, 17 in each group, were randomly assigned to coronary artery bypass grafting surgery performed either with...
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| Format: | Article |
| Language: | English |
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Wiley
2007-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2007/72356 |
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| author | Manuela Kudlova Pavel Kunes Martina Kolackova Vladimir Lonsky Jiri Mandak Ctirad Andrys Karolina Jankovicova Jan Krejsek |
| author_facet | Manuela Kudlova Pavel Kunes Martina Kolackova Vladimir Lonsky Jiri Mandak Ctirad Andrys Karolina Jankovicova Jan Krejsek |
| author_sort | Manuela Kudlova |
| collection | DOAJ |
| description | Objectives. The changes in the serum levels of lipopolysaccharide binding protein
(LBP) and sCD14 during cardiac surgery were followed in this study.
Design. Thirty-four patients, 17 in each group, were randomly assigned to coronary artery
bypass grafting surgery
performed either with (“on-pump”) or without (“off-pump”) cardiopulmonary
bypass. LBP and sCD14 were evaluated
by ELISA. Results. The serum levels of LBP were gradually increased from the 1st
postoperative day and reached their
maximum on the 3rd postoperative day in both “on-pump” and
“off-pump” patients (30.33±9.96μg/mL; 37.99±16.58μg/mL), respectively.
There were no significant differences between “on-pump” and “off-pump” patients
regarding LBP. The significantly increased levels of sCD14
from the 1st up to the 7th postoperative day in both “on-pump”
and “off-pump” patients were found with no significant differences between these groups. No
correlations between LBP and sCD14 and IL-6, CRP and long pentraxin PTX3 levels were found.
Conclusions. The levels of LBP and sCD14 are elevated in cardiac surgical patients being
similar in both groups.
These molecules are not produced as acute phase proteins in these patients. |
| format | Article |
| id | doaj-art-1d6e1e0372324e41bd145b4a898f89ad |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2007-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1d6e1e0372324e41bd145b4a898f89ad2025-02-03T05:45:35ZengWileyMediators of Inflammation0962-93511466-18612007-01-01200710.1155/2007/7235672356Lipopolysaccharide Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac SurgeryManuela Kudlova0Pavel Kunes1Martina Kolackova2Vladimir Lonsky3Jiri Mandak4Ctirad Andrys5Karolina Jankovicova6Jan Krejsek7Institute of Clinical Immunology and Allergology, Charles University in Prague, School of Medicine and University Hospital in Hradec Králové, Hradec Kralove 500 05, Czech RepublicInstitute of Clinical Immunology and Allergology, Charles University in Prague, School of Medicine and University Hospital in Hradec Králové, Hradec Kralove 500 05, Czech RepublicInstitute of Clinical Immunology and Allergology, Charles University in Prague, School of Medicine and University Hospital in Hradec Králové, Hradec Kralove 500 05, Czech RepublicDepartment of Cardiac Surgery, Charles University in Prague, School of Medicine and University Hospital in Hradec Králové, Hradec Kralove 500 05, Czech RepublicDepartment of Cardiac Surgery, Charles University in Prague, School of Medicine and University Hospital in Hradec Králové, Hradec Kralove 500 05, Czech RepublicInstitute of Clinical Immunology and Allergology, Charles University in Prague, School of Medicine and University Hospital in Hradec Králové, Hradec Kralove 500 05, Czech RepublicInstitute of Clinical Immunology and Allergology, Charles University in Prague, School of Medicine and University Hospital in Hradec Králové, Hradec Kralove 500 05, Czech RepublicInstitute of Clinical Immunology and Allergology, Charles University in Prague, School of Medicine and University Hospital in Hradec Králové, Hradec Kralove 500 05, Czech RepublicObjectives. The changes in the serum levels of lipopolysaccharide binding protein (LBP) and sCD14 during cardiac surgery were followed in this study. Design. Thirty-four patients, 17 in each group, were randomly assigned to coronary artery bypass grafting surgery performed either with (“on-pump”) or without (“off-pump”) cardiopulmonary bypass. LBP and sCD14 were evaluated by ELISA. Results. The serum levels of LBP were gradually increased from the 1st postoperative day and reached their maximum on the 3rd postoperative day in both “on-pump” and “off-pump” patients (30.33±9.96μg/mL; 37.99±16.58μg/mL), respectively. There were no significant differences between “on-pump” and “off-pump” patients regarding LBP. The significantly increased levels of sCD14 from the 1st up to the 7th postoperative day in both “on-pump” and “off-pump” patients were found with no significant differences between these groups. No correlations between LBP and sCD14 and IL-6, CRP and long pentraxin PTX3 levels were found. Conclusions. The levels of LBP and sCD14 are elevated in cardiac surgical patients being similar in both groups. These molecules are not produced as acute phase proteins in these patients.http://dx.doi.org/10.1155/2007/72356 |
| spellingShingle | Manuela Kudlova Pavel Kunes Martina Kolackova Vladimir Lonsky Jiri Mandak Ctirad Andrys Karolina Jankovicova Jan Krejsek Lipopolysaccharide Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac Surgery Mediators of Inflammation |
| title | Lipopolysaccharide Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac Surgery |
| title_full | Lipopolysaccharide Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac Surgery |
| title_fullStr | Lipopolysaccharide Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac Surgery |
| title_full_unstemmed | Lipopolysaccharide Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac Surgery |
| title_short | Lipopolysaccharide Binding Protein and sCD14 are Not Produced as Acute Phase Proteins in Cardiac Surgery |
| title_sort | lipopolysaccharide binding protein and scd14 are not produced as acute phase proteins in cardiac surgery |
| url | http://dx.doi.org/10.1155/2007/72356 |
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