Accurate RNA velocity estimation based on multibatch network reveals complex lineage in batch scRNA-seq data

Accurate RNA velocity estimation based on multibatch network reveals complex lineage in batch scRNA-seq data

Abstract RNA velocity, as an extension of trajectory inference, is an effective method for understanding cell development using single-cell RNA sequencing (scRNA-seq) experiments. However, existing RNA velocity methods are limited by the batch effect because they cannot directly correct for batch ef...

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Bibliographic Details
Main Authors: Zhaoyang Huang, Xinyang Guo, Jie Qin, Lin Gao, Fen Ju, Chenguang Zhao, Liang Yu
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Biology
Subjects:
scRNA-seq data
RNA velocity
Batch effect
Complex lineage
Optimal transport
Online Access:https://doi.org/10.1186/s12915-024-02085-8
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https://doi.org/10.1186/s12915-024-02085-8

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