Dual GSK-3β/HDAC Inhibitors Enhance the Efficacy of Macrophages to Control <i>Mycobacterium tuberculosis</i> Infection

Dual GSK-3β/HDAC Inhibitors Enhance the Efficacy of Macrophages to Control <i>Mycobacterium tuberculosis</i> Infection

Multitarget drug discovery, including host-directed therapy, is particularly promising for tuberculosis (TB) due to the resilience of <i>Mycobacterium tuberculosis</i> (Mtb) as well as the complexity of the host’s immune response. In this proof-of-concept study, we used high-content imag...

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Bibliographic Details
Main Authors: Sadaf Kalsum, Ruilan Xu, Mira Akber, Shengjie Huang, Maria Lerm, Yuqing Chen, Magda Lourda, Yang Zhou, Susanna Brighenti
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biomolecules
Subjects:
tuberculosis
<i>Mycobacterium tuberculosis</i>
macrophage
host-directed therapy
compound
glycogen synthase kinase 3 beta (GSK-3β)
Online Access:https://www.mdpi.com/2218-273X/15/4/550
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