Ghrelin对脓毒症大鼠肺泡巨噬细胞炎症信号通路Akt、NF-κB和iNOS的影响
: 【目的】观察生长激素释放肽(ghrelin)对脓毒症大鼠肺泡巨噬细胞(AM)炎症信号通路蛋白激酶 B (Akt)、核因子-κB(NF-κB)及诱导型一氧化氮合成酶(iNOS)的影响。【方法】24只SD雄性大鼠随机分为假手术 (Sham)组、脓毒症(CLP)组、ghrelin干预(CLP+ghrelin)组与ghrelin对照(Sham+ghrelin)组。盲肠结扎穿孔(CLP)构建 大鼠脓毒症模型,分别于术后3 h与5 h腹腔注射20 nmol/kg ghrelin进行干预。观察各组肺组织病理改变并评分;从 支气管肺泡灌洗液(BALF)中提取AM,ELISA测定BALF中炎症因子白...
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Main Authors: | , , , |
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Format: | Article |
Language: | zho |
Published: |
Editorial Office of Journal of Sun Yat-sen University
2018-01-01
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Series: | Zhongshan Daxue xuebao. Yixue kexue ban |
Subjects: | |
Online Access: | http://xuebaoyx.sysu.edu.cn/zh/article/43568339/ |
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