Randomized clinical trial of a digital integrative medicine intervention among patients undergoing active cancer treatment
Abstract Exercise and mindfulness-based interventions have growing evidence for managing fatigue and comorbid symptoms; however, packaging them in a cohesive digital way for patients undergoing cancer treatment has not been evaluated. We conducted a randomized controlled trial to assess the impact o...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Digital Medicine |
| Online Access: | https://doi.org/10.1038/s41746-024-01387-z |
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| author | Jun J. Mao Karolina Bryl Erin F. Gillespie Angela Green Tony K. W. Hung Raymond Baser Katherine Panageas Michael A. Postow Bobby Daly |
| author_facet | Jun J. Mao Karolina Bryl Erin F. Gillespie Angela Green Tony K. W. Hung Raymond Baser Katherine Panageas Michael A. Postow Bobby Daly |
| author_sort | Jun J. Mao |
| collection | DOAJ |
| description | Abstract Exercise and mindfulness-based interventions have growing evidence for managing fatigue and comorbid symptoms; however, packaging them in a cohesive digital way for patients undergoing cancer treatment has not been evaluated. We conducted a randomized controlled trial to assess the impact of a 12 week digital integrative medicine program, Integrative Medicine at Home (IM@Home), versus enhanced usual care on fatigue severity (primary outcome), comorbid symptoms and acute healthcare utilization (secondary outcomes), in 200 patients with solid tumors experiencing fatigue during treatment. Fatigue severity decreased more in IM@Home than in the control (1.99 vs. 1.51 points; p = 0.04). IM@Home participants also had reduced symptom distress (p = 0.003), anxiety (p = 0.03), and depression (p = 0.02). Acute healthcare utilization was lower with IM@Home, with fewer emergency department visits (rate ratio 0.49; p = 0.04), hospitalizations (4% vs. 12.9%; p = 0.03), and shorter hospital stays (4.25 vs. 10 days; p < 0.001). These promising findings should be confirmed in phase III clinical trials. “Study registered at clinicaltrials.gov (NCT05053230) on 09-20-2021”. |
| format | Article |
| id | doaj-art-1d00aeec4d7e43e0851fe718246a16e8 |
| institution | Kabale University |
| issn | 2398-6352 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Digital Medicine |
| spelling | doaj-art-1d00aeec4d7e43e0851fe718246a16e82025-01-19T12:39:52ZengNature Portfolionpj Digital Medicine2398-63522025-01-01811910.1038/s41746-024-01387-zRandomized clinical trial of a digital integrative medicine intervention among patients undergoing active cancer treatmentJun J. Mao0Karolina Bryl1Erin F. Gillespie2Angela Green3Tony K. W. Hung4Raymond Baser5Katherine Panageas6Michael A. Postow7Bobby Daly8Integrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer CenterIntegrative Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Radiation Oncology, University of Washington School of Medicine / Fred Hutchinson Cancer CenterGynecologic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer CenterHead and Neck Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer CenterDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer CenterDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer CenterMelanoma Service, Department of Medicine, Memorial Sloan Kettering Cancer CenterThoracic Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer CenterAbstract Exercise and mindfulness-based interventions have growing evidence for managing fatigue and comorbid symptoms; however, packaging them in a cohesive digital way for patients undergoing cancer treatment has not been evaluated. We conducted a randomized controlled trial to assess the impact of a 12 week digital integrative medicine program, Integrative Medicine at Home (IM@Home), versus enhanced usual care on fatigue severity (primary outcome), comorbid symptoms and acute healthcare utilization (secondary outcomes), in 200 patients with solid tumors experiencing fatigue during treatment. Fatigue severity decreased more in IM@Home than in the control (1.99 vs. 1.51 points; p = 0.04). IM@Home participants also had reduced symptom distress (p = 0.003), anxiety (p = 0.03), and depression (p = 0.02). Acute healthcare utilization was lower with IM@Home, with fewer emergency department visits (rate ratio 0.49; p = 0.04), hospitalizations (4% vs. 12.9%; p = 0.03), and shorter hospital stays (4.25 vs. 10 days; p < 0.001). These promising findings should be confirmed in phase III clinical trials. “Study registered at clinicaltrials.gov (NCT05053230) on 09-20-2021”.https://doi.org/10.1038/s41746-024-01387-z |
| spellingShingle | Jun J. Mao Karolina Bryl Erin F. Gillespie Angela Green Tony K. W. Hung Raymond Baser Katherine Panageas Michael A. Postow Bobby Daly Randomized clinical trial of a digital integrative medicine intervention among patients undergoing active cancer treatment npj Digital Medicine |
| title | Randomized clinical trial of a digital integrative medicine intervention among patients undergoing active cancer treatment |
| title_full | Randomized clinical trial of a digital integrative medicine intervention among patients undergoing active cancer treatment |
| title_fullStr | Randomized clinical trial of a digital integrative medicine intervention among patients undergoing active cancer treatment |
| title_full_unstemmed | Randomized clinical trial of a digital integrative medicine intervention among patients undergoing active cancer treatment |
| title_short | Randomized clinical trial of a digital integrative medicine intervention among patients undergoing active cancer treatment |
| title_sort | randomized clinical trial of a digital integrative medicine intervention among patients undergoing active cancer treatment |
| url | https://doi.org/10.1038/s41746-024-01387-z |
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