Serum Levels of TNF-α, IL-12/23 p40, and IL-17 in Psoriatic Patients with and without Nail Psoriasis: A Cross-Sectional Study
Nail involvement has started playing a major role in the overall assessment and management of psoriatic disease. Biologics indicated for moderate to severe chronic plaque psoriasis are shown to be beneficial in nail disease. This study aimed to assess and compare the serum levels of TNF-α, IL-12/23...
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/508178 |
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| author | Aikaterini Kyriakou Aikaterini Patsatsi Timoleon-Achilleas Vyzantiadis Dimitrios Sotiriadis |
| author_facet | Aikaterini Kyriakou Aikaterini Patsatsi Timoleon-Achilleas Vyzantiadis Dimitrios Sotiriadis |
| author_sort | Aikaterini Kyriakou |
| collection | DOAJ |
| description | Nail involvement has started playing a major role in the overall assessment and management of psoriatic disease. Biologics indicated for moderate to severe chronic plaque psoriasis are shown to be beneficial in nail disease. This study aimed to assess and compare the serum levels of TNF-α, IL-12/23 p40, and IL-17 in psoriatic patients with and without nail involvement. 52 consecutively selected patients with chronic plaque psoriasis were included in this cross-sectional study. Patients were studied and analyzed after they had been divided into 2 groups regarding the presence (n = 24) or not (n = 28) of nail psoriasis. The mean serum levels of TNF-α were significantly higher in the group of psoriatic patients with nail lesions compared to those without (t-test; 5.40 ± 1.17 versus 3.80 ± 1.63, P = 0.026). However, the median serum levels of both IL-12/23 p40 (Mann-Whitney; 92.52 (34.35–126.87) versus 150.68 (35.18–185.86), P = 0.297) and IL-17 (Mann-Whitney; 28.49 (0.00–28.49) versus 8.59 (0.00–8.59), P = 0.714) did not significantly differ between the 2 groups. These results confirm the important role of TNF-α in the pathogenesis of nail psoriasis and may suggest that anti-TNF agents could be more beneficial in psoriatic nail disease than agents targeting IL-12/23 p40 or IL-17 and its receptors. |
| format | Article |
| id | doaj-art-1cfe15ea7aea4c9d9acf361af3b0d598 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-1cfe15ea7aea4c9d9acf361af3b0d5982025-02-03T00:59:18ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/508178508178Serum Levels of TNF-α, IL-12/23 p40, and IL-17 in Psoriatic Patients with and without Nail Psoriasis: A Cross-Sectional StudyAikaterini Kyriakou0Aikaterini Patsatsi1Timoleon-Achilleas Vyzantiadis2Dimitrios Sotiriadis32nd Department of Dermatology and Venereology, Papageorgiou General Hospital, Aristotle University School of Medicine, Ring Road Thessalonikis, Nea Efkarpia, 56403 Thessaloniki, Greece2nd Department of Dermatology and Venereology, Papageorgiou General Hospital, Aristotle University School of Medicine, Ring Road Thessalonikis, Nea Efkarpia, 56403 Thessaloniki, Greece1st Department of Microbiology, Aristotle University School of Medicine, 54124 Thessaloniki, Greece2nd Department of Dermatology and Venereology, Papageorgiou General Hospital, Aristotle University School of Medicine, Ring Road Thessalonikis, Nea Efkarpia, 56403 Thessaloniki, GreeceNail involvement has started playing a major role in the overall assessment and management of psoriatic disease. Biologics indicated for moderate to severe chronic plaque psoriasis are shown to be beneficial in nail disease. This study aimed to assess and compare the serum levels of TNF-α, IL-12/23 p40, and IL-17 in psoriatic patients with and without nail involvement. 52 consecutively selected patients with chronic plaque psoriasis were included in this cross-sectional study. Patients were studied and analyzed after they had been divided into 2 groups regarding the presence (n = 24) or not (n = 28) of nail psoriasis. The mean serum levels of TNF-α were significantly higher in the group of psoriatic patients with nail lesions compared to those without (t-test; 5.40 ± 1.17 versus 3.80 ± 1.63, P = 0.026). However, the median serum levels of both IL-12/23 p40 (Mann-Whitney; 92.52 (34.35–126.87) versus 150.68 (35.18–185.86), P = 0.297) and IL-17 (Mann-Whitney; 28.49 (0.00–28.49) versus 8.59 (0.00–8.59), P = 0.714) did not significantly differ between the 2 groups. These results confirm the important role of TNF-α in the pathogenesis of nail psoriasis and may suggest that anti-TNF agents could be more beneficial in psoriatic nail disease than agents targeting IL-12/23 p40 or IL-17 and its receptors.http://dx.doi.org/10.1155/2014/508178 |
| spellingShingle | Aikaterini Kyriakou Aikaterini Patsatsi Timoleon-Achilleas Vyzantiadis Dimitrios Sotiriadis Serum Levels of TNF-α, IL-12/23 p40, and IL-17 in Psoriatic Patients with and without Nail Psoriasis: A Cross-Sectional Study The Scientific World Journal |
| title | Serum Levels of TNF-α, IL-12/23 p40, and IL-17 in Psoriatic Patients with and without Nail Psoriasis: A Cross-Sectional Study |
| title_full | Serum Levels of TNF-α, IL-12/23 p40, and IL-17 in Psoriatic Patients with and without Nail Psoriasis: A Cross-Sectional Study |
| title_fullStr | Serum Levels of TNF-α, IL-12/23 p40, and IL-17 in Psoriatic Patients with and without Nail Psoriasis: A Cross-Sectional Study |
| title_full_unstemmed | Serum Levels of TNF-α, IL-12/23 p40, and IL-17 in Psoriatic Patients with and without Nail Psoriasis: A Cross-Sectional Study |
| title_short | Serum Levels of TNF-α, IL-12/23 p40, and IL-17 in Psoriatic Patients with and without Nail Psoriasis: A Cross-Sectional Study |
| title_sort | serum levels of tnf α il 12 23 p40 and il 17 in psoriatic patients with and without nail psoriasis a cross sectional study |
| url | http://dx.doi.org/10.1155/2014/508178 |
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