Assembly of CCR5 with gp120 inhibits the HIV infectivity specifically in T cells

Assembly of CCR5 with gp120 inhibits the HIV infectivity specifically in T cells

Abstract For the entry of R5 human immunodeficiency virus type 1 (HIV-1) into target cells, CCR5 functions as a coreceptor following the binding of the envelope glycoprotein gp120 to the receptor CD4. While CD4 is known to be strongly downregulated after infection, the fate of CCR5 post-infection re...

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Bibliographic Details
Main Authors: Joyce Appiah-Kubi, Yuan Yuzhe, Takeo Kuwata, Hiromi Terasawa, Perpetual Nyame, Wright Ofotsu Amesimeku, Md. Jakir Hossain, Shuzo Matsushita, Tomohiro Sawa, Yosuke Maeda, Shinji Harada, Keisuke Yusa, Kazuaki Monde
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
HIV-1
Assembly
CCR5 incorporation
CCR5 epitope mask
Online Access:https://doi.org/10.1038/s41598-025-12653-9
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