Applications and challenges of immunotherapy in the management of gastric adenocarcinoma: current status and future perspectives

Applications and challenges of immunotherapy in the management of gastric adenocarcinoma: current status and future perspectives

Abstract Gastric adenocarcinoma (GAC) remains a significant global public health challenge, characterized by high incidence and mortality rates. Progress in tumor immunology has introduced immune checkpoint inhibitors (ICIs) targeting the programmed cell death-1 (PD-1)/programmed cell death-ligand 1...

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Bibliographic Details
Main Authors: Zhiyao Chen, Yunbin Ma, Jianan Chen
Format: Article
Language:English
Published: BMC 2025-03-01
Series:World Journal of Surgical Oncology
Subjects:
Gastric adenocarcinoma
Immunotherapy
Immune checkpoint inhibitors
PD-1/PD-L1
CTLA-4
Immune evasion
Online Access:https://doi.org/10.1186/s12957-025-03752-y
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