Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia

Thrombin cleaves membrane-bound endoglin potentially contributing to the heterogeneity of circulating endoglin in preeclampsia

Abstract Increased levels of soluble endoglin (sEng) are found in serum, plasma, and urine of preeclampsia patients. sEng is released from membrane-bound endoglin through the proteolytic activity of metalloproteases, but its structural heterogeneity suggests the involvement of additional proteases....

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Main Authors: Divina El Hamaoui, Aurore Marchelli, Sophie Gandrille, Etienne Reboul, Alain Stepanian, Bruno Palmier, Luca Jovine, Franck Lebrin, David M. Smadja, Carmelo Bernabeu, Cecile V. Denis, Pascale Gaussem, Samuela Pasquali, Alexandre Kauskot, Elisa Rossi
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07751-3
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https://doi.org/10.1038/s42003-025-07751-3

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