T lymphocyte heterogeneity in NSCLC: implications for biomarker development and therapeutic innovation

T lymphocyte heterogeneity in NSCLC: implications for biomarker development and therapeutic innovation

Non-small cell lung cancer (NSCLC) immunotherapy has been revolutionized by immune checkpoint inhibitors (ICIs), yet response heterogeneity persists due to dynamic tumor-immune interactions. This review summarizes recent studies in understanding tumor-infiltrating lymphocyte (TIL) biology, highlight...

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Bibliographic Details
Main Authors:	Yu Liu, Denghui Qin, Jiejun Fu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-05-01
Series:	Frontiers in Immunology
Subjects:	melanoma T lymphocyte CD8 + T cell PD-1 NRAS mutations immunotherapy combination therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1604310/full
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