Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss
Aims. We investigated the relationship between circulating amino acid levels and obesity; to what extent weight loss followed by weight maintenance can correct amino acid abnormalities; and whether amino acids are related to weight loss. Methods. Amino acids associated with waist circumference (WC)...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2017/6490473 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562791305707520 |
|---|---|
| author | Nina Geidenstam Martin Magnusson Anders P. H. Danielsson Robert E. Gerszten Thomas J. Wang Lovisa E. Reinius Hindrik Mulder Olle Melander Martin Ridderstråle |
| author_facet | Nina Geidenstam Martin Magnusson Anders P. H. Danielsson Robert E. Gerszten Thomas J. Wang Lovisa E. Reinius Hindrik Mulder Olle Melander Martin Ridderstråle |
| author_sort | Nina Geidenstam |
| collection | DOAJ |
| description | Aims. We investigated the relationship between circulating amino acid levels and obesity; to what extent weight loss followed by weight maintenance can correct amino acid abnormalities; and whether amino acids are related to weight loss. Methods. Amino acids associated with waist circumference (WC) and BMI were studied in 804 participants from the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC). Changes in amino acid levels were analyzed after weight loss and weight maintenance in 12 obese subjects and evaluated in a replication cohort (n=83). Results. Out of the eight identified BMI-associated amino acids from the MDC-CC, alanine, isoleucine, tyrosine, phenylalanine, and glutamate decreased after weight loss, while asparagine increased after weight maintenance. These changes were validated in the replication cohort. Scores that were constructed based on obesity-associated amino acids and known risk factors decreased in the ≥10% weight loss group with an associated change in BMI (R2=0.16–0.22, p<0.002), whereas the scores increased in the <10% weight loss group (p<0.0004). Conclusions. Weight loss followed by weight maintenance leads to differential changes in amino acid levels associated with obesity. Treatment modifiable scores based on epidemiological and interventional data may be used to evaluate the potential metabolic benefit of weight loss. |
| format | Article |
| id | doaj-art-1cae56bc33c1484b9a54d1e865244957 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-1cae56bc33c1484b9a54d1e8652449572025-02-03T01:21:42ZengWileyInternational Journal of Endocrinology1687-83371687-83452017-01-01201710.1155/2017/64904736490473Amino Acid Signatures to Evaluate the Beneficial Effects of Weight LossNina Geidenstam0Martin Magnusson1Anders P. H. Danielsson2Robert E. Gerszten3Thomas J. Wang4Lovisa E. Reinius5Hindrik Mulder6Olle Melander7Martin Ridderstråle8Department of Clinical Sciences Malmö, Clinical Obesity, Lund University Diabetes Center, Lund University, Malmö, SwedenDepartment of Cardiology, Skåne University Hospital, Malmö, SwedenDepartment of Clinical Sciences Malmö, Clinical Obesity, Lund University Diabetes Center, Lund University, Malmö, SwedenCardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USADivision of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN, USADepartment of Clinical Sciences Malmö, Clinical Obesity, Lund University Diabetes Center, Lund University, Malmö, SwedenDepartment of Clinical Sciences Malmö, Molecular Metabolism, Lund University Diabetes Center, Lund University, Malmö, SwedenDepartment of Cardiology, Skåne University Hospital, Malmö, SwedenDepartment of Clinical Sciences Malmö, Clinical Obesity, Lund University Diabetes Center, Lund University, Malmö, SwedenAims. We investigated the relationship between circulating amino acid levels and obesity; to what extent weight loss followed by weight maintenance can correct amino acid abnormalities; and whether amino acids are related to weight loss. Methods. Amino acids associated with waist circumference (WC) and BMI were studied in 804 participants from the Malmö Diet and Cancer Cardiovascular Cohort (MDC-CC). Changes in amino acid levels were analyzed after weight loss and weight maintenance in 12 obese subjects and evaluated in a replication cohort (n=83). Results. Out of the eight identified BMI-associated amino acids from the MDC-CC, alanine, isoleucine, tyrosine, phenylalanine, and glutamate decreased after weight loss, while asparagine increased after weight maintenance. These changes were validated in the replication cohort. Scores that were constructed based on obesity-associated amino acids and known risk factors decreased in the ≥10% weight loss group with an associated change in BMI (R2=0.16–0.22, p<0.002), whereas the scores increased in the <10% weight loss group (p<0.0004). Conclusions. Weight loss followed by weight maintenance leads to differential changes in amino acid levels associated with obesity. Treatment modifiable scores based on epidemiological and interventional data may be used to evaluate the potential metabolic benefit of weight loss.http://dx.doi.org/10.1155/2017/6490473 |
| spellingShingle | Nina Geidenstam Martin Magnusson Anders P. H. Danielsson Robert E. Gerszten Thomas J. Wang Lovisa E. Reinius Hindrik Mulder Olle Melander Martin Ridderstråle Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss International Journal of Endocrinology |
| title | Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss |
| title_full | Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss |
| title_fullStr | Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss |
| title_full_unstemmed | Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss |
| title_short | Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss |
| title_sort | amino acid signatures to evaluate the beneficial effects of weight loss |
| url | http://dx.doi.org/10.1155/2017/6490473 |
| work_keys_str_mv | AT ninageidenstam aminoacidsignaturestoevaluatethebeneficialeffectsofweightloss AT martinmagnusson aminoacidsignaturestoevaluatethebeneficialeffectsofweightloss AT andersphdanielsson aminoacidsignaturestoevaluatethebeneficialeffectsofweightloss AT robertegerszten aminoacidsignaturestoevaluatethebeneficialeffectsofweightloss AT thomasjwang aminoacidsignaturestoevaluatethebeneficialeffectsofweightloss AT lovisaereinius aminoacidsignaturestoevaluatethebeneficialeffectsofweightloss AT hindrikmulder aminoacidsignaturestoevaluatethebeneficialeffectsofweightloss AT ollemelander aminoacidsignaturestoevaluatethebeneficialeffectsofweightloss AT martinridderstrale aminoacidsignaturestoevaluatethebeneficialeffectsofweightloss |