Unveiling Multi‐Scale Architectural Features in Single‐Cell Hi‐C Data Using scCAFE

Unveiling Multi‐Scale Architectural Features in Single‐Cell Hi‐C Data Using scCAFE

Abstract Single‐cell Hi‐C (scHi‐C) has provided unprecedented insights into the heterogeneity of 3D genome organization. However, its sparse and noisy nature poses challenges for computational analyses, such as chromatin architectural feature identification. Here, scCAFE is introduced, which is a de...

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Bibliographic Details
Main Authors: Fuzhou Wang, Jiecong Lin, Hamid Alinejad‐Rokny, Wenjing Ma, Lingkuan Meng, Lei Huang, Jixiang Yu, Nanjun Chen, Yuchen Wang, Zhongyu Yao, Weidun Xie, Ka‐Chun Wong, Xiangtao Li
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:Advanced Science
Subjects:
chromatin loops
compartments
single‐cell Hi‐C
TLDs
Online Access:https://doi.org/10.1002/advs.202416432
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https://doi.org/10.1002/advs.202416432

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